Evaluation of liver fat in the presence of iron with MRI using T2* correction: a clinical approach.
Objectives: To assess magnetic resonance imaging (MRI) with conventional chemical shift-based sequences with and without T2* correction for the evaluation of steatosis hepatitis (SH) in the presence of iron.Methods: Thirty-one patients who underwent MRI and liver biopsy because of clinically suspect...
| Publicado en: | European Radiology Vol. 23; no. 6; pp. 1643 - 1650 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104073586&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104073586 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2013 vid: 23 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104073586 NLM23334458 2012121645 10.1007/s00330-012-2745-2 NLM23334458 104073586 ppf: 1643 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Evaluation of liver fat in the presence of iron with MRI using T2* correction: a clinical approach. aug: au: Benjamin, Henninger Christian, Kremser Stefan, Rauch Robert, Eder Werner, Judmaier Heinz, Zoller Henrik, Michaely Michael, Schocke Henninger, Benjamin Kremser, Christian Rauch, Stefan Eder, Robert Judmaier, Werner Zoller, Heinz Michaely, Henrik Schocke, Michael affil: Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria sug: subj: Adipose Tissue Metabolism Fatty Liver Diagnosis Fatty Liver Pathology Iron Liver Pathology Magnetic Resonance Imaging Methods Adult Aged Biopsy Female Ferritin Blood Human Image Processing, Computer Assisted Iron Metabolism Iron Overload Metabolism Liver Metabolism Male Middle Age Reproducibility of Results Retrospective Design Transferrin Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To assess magnetic resonance imaging (MRI) with conventional chemical shift-based sequences with and without T2* correction for the evaluation of steatosis hepatitis (SH) in the presence of iron.Methods: Thirty-one patients who underwent MRI and liver biopsy because of clinically suspected diffuse liver disease were retrospectively analysed. The signal intensity (SI) was calculated in co-localised regions of interest (ROIs) using conventional spoiled gradient-echo T1 FLASH in-phase and opposed-phase (IP/OP). T2* relaxation time was recorded in a fat-saturated multi-echo-gradient-echo sequence. The fat fraction (FF) was calculated with non-corrected and T2*-corrected SIs. Results were correlated with liver biopsy.Results: There was significant difference (P < 0.001) between uncorrected and T2* corrected FF in patients with SH and concomitant hepatic iron overload (HIO). Using 5 % as a threshold resulted in eight false negative results with uncorrected FF whereas T2* corrected FF lead to true positive results in 5/8 patients. ROC analysis calculated three threshold values (8.97 %, 5.3 % and 3.92 %) for T2* corrected FF with accuracy 84 %, sensitivity 83-91 % and specificity 63-88 %.Conclusions: FF with T2* correction is accurate for the diagnosis of hepatic fat in the presence of HIO. Findings of our study suggest the use of IP/OP imaging in combination with T2* correction.Key Points: • Magnetic resonance helps quantify both iron and fat content within the liver • T2* correction helps to predict the correct diagnosis of steatosis hepatitis • "Fat fraction" from T2*-corrected chemical shift-based sequences accurately quantifies hepatic fat • "Fat fraction" without T2* correction underestimates hepatic fat with iron overload. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|