Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT.
Objective: To investigate the collapsibility of the lung and individual lobes in patients with COPD during inspiration/expiration and assess the association of whole lung and lobar volume changes with pulmonary function tests (PFTs) and disease severity.Methods: PFT measures used were RV/TLC%, FEV1%...
| Published in: | European Radiology Vol. 23; no. 6; pp. 1564 - 1573 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jun2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104073590&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104073590 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2013 vid: 23 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104073590 NLM23494492 2012121648 10.1007/s00330-012-2746-1 NLM23494492 PMC3657332 104073590 ppf: 1564 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. aug: au: Kundu, Shinjini Gu, Suicheng Leader, Joseph K Tedrow, John R Sciurba, Frank C Gur, David Kaminski, Naftali Pu, Jiantao affil: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15213, USA. sug: subj: Lung Physiopathology Pulmonary Disease, Chronic Obstructive Diagnosis Pulmonary Disease, Chronic Obstructive Radiography Aged Algorithms Female Human Lung Pathology Lung Radiography Male Middle Age Radiographic Image Interpretation, Computer-Assisted Respiratory Function Tests Tomography, X-Ray Computed Methods Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: To investigate the collapsibility of the lung and individual lobes in patients with COPD during inspiration/expiration and assess the association of whole lung and lobar volume changes with pulmonary function tests (PFTs) and disease severity.Methods: PFT measures used were RV/TLC%, FEV1% predicted, FVC, FEV1/FVC%, DLco% predicted and GOLD category. A total of 360 paired inspiratory and expiratory CT examinations acquired in 180 subjects were analysed. Automated computerised algorithms were used to compute individual lobe and total lung volumes. Lung volume collapsibility was assessed quantitatively using the simple difference between CT computed inspiration (I) and expiration (E) volumes (I-E), and a relative measure of volume changes, (I-E)/I.Results: Mean absolute collapsibility (I-E) decreased in all lung lobes with increasing disease severity defined by GOLD classification. Relative collapsibility (I-E)/I showed a similar trend. Upper lobes had lower volume collapsibility across all GOLD categories and lower lobes collectively had the largest volume collapsibility. Whole lung and left lower lobe collapsibility measures tended to have the highest correlations with PFT measures. Collapsibility of lung lobes and whole lung was also negatively correlated with the degree of air trapping between expiration and inspiration, as measured by mean lung density. All measured associations were statistically significant (P < 0.01).Conclusion: Severity of COPD appears associated with increased collapsibility in the upper lobes, but change (decline) in collapsibility is faster in the lower lobes.Key Points: • Inspiratory and expiratory computed tomography allows assessment of lung collapsibility • Lobe volume collapsibility is significantly correlated with measures of lung function. • As COPD severity increases, collapsibility of individual lung lobes decreases. • Upper lobes exhibit more severe disease, while lower lobes decline faster. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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