Comparative performance of a primary-reader and second-reader paradigm of computer-aided detection for CT colonography in a low-prevalence screening population.
Objective: To compare the efficacy of computer-aided detection (CAD) for computed tomographic colonography (CTC) when employed as either primary-reader or second-reader paradigms in a low-prevalence screening population.Methods: Ninety screening patients underwent same-day CTC and colonoscopy. Four...
| Published in: | Japanese Journal of Radiology Vol. 31; no. 5; pp. 310 - 320 |
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| Main Authors: | , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
May2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104074456&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104074456 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: May2013 vid: 31 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104074456 NLM23420274 2012131074 10.1007/s11604-013-0187-7 NLM23420274 104074456 ppf: 310 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Comparative performance of a primary-reader and second-reader paradigm of computer-aided detection for CT colonography in a low-prevalence screening population. aug: au: Miyake, Mototaka Iinuma, Gen Taylor, Stuart A Halligan, Steve Morimoto, Tsuyoshi Ichikawa, Tamaki Tomimatsu, Hideto Beddoe, Gareth Sugimura, Kazuro Arai, Yasuaki affil: Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan, neripuroct@yahoo.co.jp. sug: subj: Colonic Polyps Radiography Colonography, Computed Tomographic Methods Diagnosis, Computer Assisted False Positive Results Female Human Male Middle Age Predictive Value of Tests Prospective Studies ROC Curve Random Assignment Sensitivity and Specificity Middle Aged: 45-64 years Female Male ab: Objective: To compare the efficacy of computer-aided detection (CAD) for computed tomographic colonography (CTC) when employed as either primary-reader or second-reader paradigms in a low-prevalence screening population.Methods: Ninety screening patients underwent same-day CTC and colonoscopy. Four readers prospectively interpreted all CTC data sets using a second-reader paradigm (unassisted interpretation followed immediately by CAD assistance). Three months later, randomized anonymous data sets were re-interpreted by all readers using a primary-reader paradigm (only CAD prompts evaluated).Results: Compared with the average per-patient sensitivity for unassisted interpretation (0.57), both CAD paradigms significantly increased sensitivity: 0.78 (p < 0.001) for the second-reader paradigm and 0.83 (p < 0.001) for the primary-reader paradigm. There was no significant difference between CAD paradigms (p = 0.25). The average per-patient specificity for polyps ≥6 mm was significantly higher using the primary-reader paradigm than the second-reader paradigm (0.90 vs. 0.83, respectively, p = 0.006), with ROC AUCs of 0.83 and 0.68, respectively. Reading time using CAD as a primary-reader paradigm (median 1.4 min) was significantly shorter than both unassisted (median 4.0 min, p < 0.001) and second-reader paradigms (median 5.5 min, p < 0.001).Conclusion: CAD improves radiologist sensitivity in screening patients when used as either a second- or primary-reader paradigm, although the latter may improve specificity and efficiency more. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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