Viable residual tumor tissue after radiofrequency ablation treatment in hepatocellular carcinoma: evaluation with CT perfusion.
Purpose: To assess the role of CT perfusion technique in detection of blood flow changes related to the therapeutic effects in HCC lesion treated with RFA. Methods: 14 cirrhotic patients with known HCC underwent a perfusion study about 4 months (range 1-13 months) after RFA on a 16-slice MDCT scanne...
| Published in: | Abdominal Imaging Vol. 38; no. 3; pp. 502 - 511 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jun2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104076087&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104076087 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09428925 O52 jtl: Abdominal Imaging issn: 09428925 maglogo: N pubinfo: dt: Jun2013 vid: 38 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104076087 NLM22743839 2012142924 10.1007/s00261-012-9924-0 NLM22743839 104076087 ppf: 502 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Viable residual tumor tissue after radiofrequency ablation treatment in hepatocellular carcinoma: evaluation with CT perfusion. aug: au: Ippolito, Davide Bonaffini, Pietro Andrea Capraro, Cristina Leni, Davide Corso, Rocco Sironi, Sandro affil: School of Medicine, University of Milano-Bicocca, Milan, Via Pergolesi 33, 20900, Monza, MB, Italy, davide.atena@tiscalinet.it. sug: subj: Carcinoma, Hepatocellular Radiography Carcinoma, Hepatocellular Surgery Catheter Ablation Liver Neoplasms Radiography Liver Neoplasms Surgery Aged Aged, 80 and Over Carcinoma, Hepatocellular Pathology Female Image Processing, Computer Assisted Liver Neoplasms Pathology Male Middle Age Neoplastic Processes Radiography, Interventional Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: To assess the role of CT perfusion technique in detection of blood flow changes related to the therapeutic effects in HCC lesion treated with RFA. Methods: 14 cirrhotic patients with known HCC underwent a perfusion study about 4 months (range 1-13 months) after RFA on a 16-slice MDCT scanner (Brilliance, Philips). Dynamic CT was performed acquiring 8 dynamic slice/scan, after injection of 50 mL of contrast media. In treated lesion, surrounding parenchyma and hypervascular tissue suspicious for residual disease/recurrence, the following perfusion parameters were analyzed: perfusion (P, mL/100 g min); arterial perfusion (AP, mL/min); blood volume (BV, mL/100 mg); hepatic perfusion index (HPI, %), and time to peak (TTP, s). Univariate Wilcoxon signed rank test was used for statistical analysis. Results: In patients with residual disease (8/14) values of perfusion parameters measured within tumor were: P, median = 45.2; AP, median = 48.2; BV, median = 18.9; HPI, median = 35.8; and TTP, median = 19.4. The values calculated in ablated area were: P, median = 10.9; AP, median = 9.6; BV, median = 5.5; HPI, median = 14.6; TTP, median = 39.6. The parameters calculated in the surrounding parenchyma were: P, median = 15.8; AP, median = 14.2; BV, median = 12.0; HPI, median = 17.9; TTP, median = 43.2. A significant difference (P < 0.05) was observed in mean values of P, AP, and HPI, calculated between treated lesions with residual tumor and those successfully treated. Conclusion: Perfusion CT enables assessment of HCC vascularity after RFA treatment, by adding quantitative information about the presence of residual arterial vessels within the viable residual neoplastic tissue. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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