Use of genetic programming, logistic regression, and artificial neural nets to predict readmission after coronary artery bypass surgery.

As many as 14 % of patients undergoing coronary artery bypass surgery are readmitted within 30 days. Readmission is usually the result of morbidity and may lead to death. The purpose of this study is to develop and compare statistical and genetic programming models to predict readmission. Patients w...

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Publicado en:Journal of Clinical Monitoring & Computing Vol. 27; no. 4; pp. 455 - 465
Autores principales: Engoren, Milo, Habib, Robert H, Dooner, John J, Schwann, Thomas A
Formato: research Journal Article
Publicado: Springer Nature Aug2013
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Use of genetic programming, logistic regression, and artificial neural nets to predict readmission after coronary artery bypass surgery.
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          Engoren, Milo
          Habib, Robert H
          Dooner, John J
          Schwann, Thomas A
        affil: Department of Anesthesiology, University of Michigan, 4172 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5861, USA, engorenm@med.umich.edu.
      sug:
        subj:
          Coronary Artery Bypass
          Readmission
          Algorithms
          Pharmacokinetics
          Artificial Intelligence
          Chromosomes
          Coronary Arteriosclerosis Surgery
          Female
          Human
          Logistic Regression
          Male
          Neural Networks (Computer)
          Programming Languages
          ROC Curve
          Random Assignment
          Regression
          Reproducibility of Results
          Risk Assessment
          Risk Factors
          Software
          Female
          Male
      ab: As many as 14 % of patients undergoing coronary artery bypass surgery are readmitted within 30 days. Readmission is usually the result of morbidity and may lead to death. The purpose of this study is to develop and compare statistical and genetic programming models to predict readmission. Patients were divided into separate Construction and Validation populations. Using 88 variables, logistic regression, genetic programs, and artificial neural nets were used to develop predictive models. Models were first constructed and tested on the Construction populations, then validated on the Validation population. Areas under the receiver operator characteristic curves (AU ROC) were used to compare the models. Two hundred and two patients (7.6 %) in the 2,644 patient Construction group and 216 (8.0 %) of the 2,711 patient Validation group were re-admitted within 30 days of CABG surgery. Logistic regression predicted readmission with AU ROC = .675 ± .021 in the Construction group. Genetic programs significantly improved the accuracy, AU ROC = .767 ± .001, p < .001). Artificial neural nets were less accurate with AU ROC = 0.597 ± .001 in the Construction group. Predictive accuracy of all three techniques fell in the Validation group. However, the accuracy of genetic programming (AU ROC = .654 ± .001) was still trivially but statistically non-significantly better than that of the logistic regression (AU ROC = .644 ± .020, p = .61). Genetic programming and logistic regression provide alternative methods to predict readmission that are similarly accurate.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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