Reduced complexity of intracranial pressure observed in short time series of intracranial hypertension following traumatic brain injury in adults.
Physiological parameters, such as intracranial pressure (ICP), are regulated by interconnected feedback loops, resulting in a complex time course. According to the decomplexification theory, disease is characterised by a loss of feedback loops resulting in a reduced complexity of the time course of...
| Publicado en: | Journal of Clinical Monitoring & Computing Vol. 27; no. 4; pp. 395 - 404 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104078506&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104078506 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13871307 OHC jtl: Journal of Clinical Monitoring & Computing issn: 13871307 maglogo: N pubinfo: dt: Aug2013 vid: 27 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104078506 NLM23306818 2012165898 10.1007/s10877-012-9427-0 NLM23306818 104078506 ppf: 395 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Reduced complexity of intracranial pressure observed in short time series of intracranial hypertension following traumatic brain injury in adults. aug: au: Soehle, Martin Gies, Bernadette Smielewski, Peter Czosnyka, Marek affil: Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany, martin.soehle@ukb.uni-bonn.de. sug: subj: Blood Pressure Determination Equipment and Supplies Blood Pressure Determination Methods Brain Injuries Physiopathology Intracranial Hypertension Physiopathology Intracranial Pressure Monitoring, Physiologic Equipment and Supplies Adult Brain Injuries Complications Female Human Intracranial Hypertension Complications Male Middle Age Monitoring, Physiologic Methods Retrospective Design Software Time Factors Young Adult Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Physiological parameters, such as intracranial pressure (ICP), are regulated by interconnected feedback loops, resulting in a complex time course. According to the decomplexification theory, disease is characterised by a loss of feedback loops resulting in a reduced complexity of the time course of physiological parameters. We hypothesized that complexity of the ICP time series is decreased during periods of intracranial hypertension (IHT) following adult traumatic brain injury. In an observational retrospective cohort study, ICP was continuously monitored using intraparenchymally implanted probes and stored using ICM + -software. Periods of IHT (ICP > 25 mmHg for at least 1,024 s), were compared with preceding periods of intracranial normotension (ICP < 20 mmHg) and analysed at 1 s-intervals. ICP data (length = 1,024 s) were normalised (mean = 0, SD = 1) and complexity was estimated using the scaling exponent α (as derived from detrended fluctuation analysis), sample entropy (SampEn, m = 1, r = 0.2 × SD) and multiscale entropy. 344 episodes were analysed in 22 patients. During IHT (ICP = 31.7 ± 7.8 mmHg, mean ± SD), α was significantly elevated (α = 1.02 ± 0.22, p < 0.001) and SampEn significantly reduced (SampEn = 1.45 ± 0.46, p = 0.004) as compared to before IHT (ICP = 15.7 ± 3.2 mmHg, α = 0.81 ± 0.14, SampEn = 1.81 ± 0.24). In addition, MSE revealed a significantly (p < 0.05) decreased entropy at scaling factors ranging from 1 to 10. Both the increase in α as well as the decrease in SampEn and MSE indicate a loss of ICP complexity. Therefore following traumatic brain injury, periods of IHT seem to be characterised by a decreased complexity of the ICP waveform. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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