Associations of interleukin-6 with vegetative but not affective depressive symptoms in terminally ill cancer patients.
Purpose: Previous studies have reported associations of depressive symptoms with pro-inflammatory cytokines, especially with interleukin-6 (IL-6) in noncancer subjects and cancer patients. Meanwhile, symptoms such as tiredness and appetite loss may be vegetative symptoms of depression when associate...
| Publicado en: | Supportive Care in Cancer Vol. 21; no. 8; pp. 2097 - 2107 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104080055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104080055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Aug2013 vid: 21 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104080055 NLM23446881 2012177077 10.1007/s00520-013-1767-x NLM23446881 104080055 ppf: 2097 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Associations of interleukin-6 with vegetative but not affective depressive symptoms in terminally ill cancer patients. aug: au: Inagaki, Masatoshi Akechi, Tatsuo Okuyama, Toru Sugawara, Yuriko Kinoshita, Hiroya Shima, Yasuo Terao, Kimio Mitsunaga, Shuichi Ochiai, Atsushi Uchitomi, Yosuke affil: Center for Suicide Prevention, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. sug: subj: Depression Blood Interleukins Blood Neoplasms Blood Terminally Ill Patients Adult Aged Anxiety Blood Anxiety Complications Anxiety Psychosocial Factors Depression Complications Depression Psychosocial Factors Fatigue Blood Fatigue Complications Fatigue Psychosocial Factors Female Human Male Middle Age Neoplasms Complications Neoplasms Psychosocial Factors Psychological Tests Scales Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: Previous studies have reported associations of depressive symptoms with pro-inflammatory cytokines, especially with interleukin-6 (IL-6) in noncancer subjects and cancer patients. Meanwhile, symptoms such as tiredness and appetite loss may be vegetative symptoms of depression when associated with other diagnostic criteria of depression. Such vegetative-type symptoms worsen during the last 6 months of life in cancer patients and may not be associated with affective depressive symptoms such as sadness and nervousness. This study explored associations between depressive symptoms and plasma IL-6 in terminally ill cancer patients whose survival period was confirmed to be less than 6 months by follow-up, with attention to differences in vegetative and affective depressive symptoms.Methods: Data from 112 consecutively recruited terminally ill cancer patients who registered at a palliative care unit without any active anticancer treatment were used. Plasma IL-6 levels were measured using an electrochemiluminescence assay. Depressive symptoms included in the DSM-IV and Cavanaugh criteria were assessed by structured interviews and were categorized into affective symptoms and vegetative symptoms. Affective symptoms were also measured with the depression subscale of the Hospital Anxiety and Depression Scale, which does not include vegetative symptoms.Results: Vegetative symptoms, such as appetite loss, insomnia, and fatigue, were significantly associated with IL-6 levels. However, neither of the affective symptoms nor their severity was associated with IL-6 levels.Conclusions: IL-6 was associated with vegetative depressive symptoms in terminally ill cancer patients but not with affective depressive symptoms, suggesting possible differences in the pathophysiological mechanisms between these sets of symptoms. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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