Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas.
Objectives: The purposes of this MR-based study were to calculate q-space imaging (QSI)-derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour ce...
| Publicado en: | European Radiology Vol. 23; no. 8; pp. 2258 - 2264 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104080243&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104080243 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2013 vid: 23 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104080243 NLM23519438 2012177786 10.1007/s00330-013-2823-0 NLM23519438 104080243 ppf: 2258 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas. aug: au: Fatima, Zareen Motosugi, Utaroh Waqar, Ahmed Bilal Hori, Masaaki Ishigame, Keiichi Oishi, Naoki Onodera, Toshiyuki Yagi, Kazuo Katoh, Ryohei Araki, Tsutomu affil: Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi, 409-3898, Japan. sug: subj: Magnetic Resonance Imaging Methods Meningeal Neoplasms Pathology Meningioma Pathology Adult Aged Aged, 80 and Over Brain Pathology Female Human Image Processing, Computer Assisted Methods Male Middle Age Observer Bias Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: The purposes of this MR-based study were to calculate q-space imaging (QSI)-derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour cell count (TCC) and MIB-1 labelling index (LI).Methods: MRI, including QSI and conventional diffusion-weighted imaging (DWI), was performed in 44 meningioma patients (52 lesions). ADC and MDP maps were acquired from post-processing of the data. Quantitative analyses of these maps were performed by applying regions of interest. Pearson correlation coefficients were calculated for ADC and MDP in all lesions and for ADC and TCC, MDP and TCC, ADC and MIB-1 LI, and MDP and MIB-1 LI in 17 patients who underwent subsequent surgery.Results: ADC and MDP values were found to have a strong correlation: r = 0.78 (P = <0.0001). Both ADC and MDP values had a significant negative association with TCC: r = -0.53 (p = 0.02) and -0.48 (P = 0.04), respectively. MIB-1 LI was not, however, found to have a significant association with these diffusion parameters.Conclusion: In meningiomas, both ADC and MDP may be representative of cell density.Key Points: • Diffusion-weighted MRI offers possibilities to assess the aggressiveness of meningiomas. • The q-space imaging-derived mean displacement correlates strongly with apparent diffusion coefficients. • Both diffusion parameters showed a strong negative association with tumour cell counts. • Derived mean displacement may help assess the aggressiveness of meningiomas preoperatively. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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