Whole-body MRI for the detection of bone marrow involvement in lymphoma: prospective study in 116 patients and comparison with FDG-PET.
Objective: To assess and compare the value of whole-body MRI with FDG-PET for detecting bone marrow involvement in lymphoma.Methods: A total of 116 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI and blind bone marrow biopsy (BMB) of the posterior iliac crest. Of 116 pa...
| Publicado en: | European Radiology Vol. 23; no. 8; pp. 2271 - 2279 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104080259&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104080259 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2013 vid: 23 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104080259 NLM23591618 2012177803 10.1007/s00330-013-2835-9 NLM23591618 104080259 ppf: 2271 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Whole-body MRI for the detection of bone marrow involvement in lymphoma: prospective study in 116 patients and comparison with FDG-PET. aug: au: Adams, Hugo J A Kwee, Thomas C Vermoolen, Malou A de Keizer, Bart de Klerk, John M H Adam, Judit A Fijnheer, Rob Kersten, Marie José Stoker, Jaap Nievelstein, Rutger A J affil: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. sug: subj: Bone Marrow Pathology Bone Marrow Neoplasms Pathology Fludeoxyglucose F 18 Diagnostic Use Lymphoma Pathology Magnetic Resonance Imaging Methods Tomography, Emission-Computed Methods Adolescence Adult Aged Aged, 80 and Over Biopsy Bone Marrow Neoplasms Female Human Lymphoma Diagnosis Male Middle Age Prospective Studies Radiopharmaceuticals Diagnostic Use Reproducibility of Results Sensitivity and Specificity Diagnostic Imaging Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: To assess and compare the value of whole-body MRI with FDG-PET for detecting bone marrow involvement in lymphoma.Methods: A total of 116 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI and blind bone marrow biopsy (BMB) of the posterior iliac crest. Of 116 patients, 80 also underwent FDG-PET. Patient-based sensitivities of whole-body MRI for detecting bone marrow involvement were calculated using BMB as reference standard and compared with FDG-PET in aggressive and indolent lymphomas separately.Results: Sensitivity of whole-body MRI in all lymphomas was 45.5 % [95 % confidence interval (CI): 29.8-62.0 %]. Sensitivity of whole-body MRI in aggressive lymphoma [88.9 % (95 % CI: 54.3-100 %)] was significantly higher (P = 0.0029) than that in indolent lymphoma [23.5 % (95 % CI: 9.1-47.8 %)]. Sensitivity of FDG-PET in aggressive lymphoma [83.3 % (95 % CI: 41.8-98.9 %)] was also significantly higher (P = 0.026) than that in indolent lymphoma [12.5 % (95 % CI: 0-49.2 %)]. There were no significant differences in sensitivity between whole-body MRI and FDG-PET (P = 1.00) CONCLUSION: Sensitivity of whole-body MRI for detecting lymphomatous bone marrow involvement is too low to (partially) replace BMB. Sensitivity of whole-body MRI is significantly higher in aggressive lymphoma than in indolent lymphoma and is equal to FDG-PET in both entities.Key Points: • Bone marrow involvement in lymphoma has prognostic and therapeutic implications. • Blind bone marrow biopsy (BMB) is standard for bone marrow assessment. • Neither whole-body MRI nor FDG-PET can yet replace BMB. • Both techniques have higher sensitivity in aggressive than in indolent lymphoma. • Both imaging techniques are complementary to BMB. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|