Liver fat volume fraction quantification with fat and water T1 and T 2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T.
Objective: To validate a magnitude-based method for fat volume fraction (FVF) quantification in the liver without any dominant component ambiguity problems and with the aim of transferring this method to any imaging system (clinical fields of 1.5 and 3.0 T).Methods: MR imaging was performed at 1.5 a...
| Publicado en: | European Radiology Vol. 23; no. 8; pp. 2175 - 2187 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104080260&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104080260 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2013 vid: 23 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104080260 104080260 NLM23588583 2012177801 10.1007/s00330-013-2826-x NLM23588583 104080260 ppf: 2175 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Liver fat volume fraction quantification with fat and water T1 and T 2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T. aug: au: Leporq, Benjamin Ratiney, Hélène Pilleul, Frank Beuf, Olivier affil: CREATIS, CNRS UMR 5220, Inserm U1044, INSA-Lyon, Université de Lyon, Université Lyon 1, bât. 308, 43, Boulevard du 11 Novembre 1918, 69616, Villeurbanne, France. sug: subj: Adipose Tissue Pathology Liver Failure Pathology Fatty Liver Pathology Liver Pathology Magnetic Resonance Spectroscopy Methods Adult Aged Algorithms Female Human Image Processing, Computer Assisted Methods Inflammation Male Middle Age Models, Theoretical Phantoms, Imaging Prospective Studies Sensitivity and Specificity Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: To validate a magnitude-based method for fat volume fraction (FVF) quantification in the liver without any dominant component ambiguity problems and with the aim of transferring this method to any imaging system (clinical fields of 1.5 and 3.0 T).Methods: MR imaging was performed at 1.5 and 3.0 T using a multiple-angle multiple-gradient echo sequence. A quantification algorithm correcting for relaxation time effects using a disjointed estimation of T1 and T2* of fat and water and accounting for the NMR spectrum of fat was developed. Validations were performed on fat-water emulsion at 1.5 and 3.0 T and compared with (1)H-MRS. This was followed by a prospective in-vivo comparative study on 28 patients with chronic liver disease and included histology.Results: Phantom study showed good agreement between MRI and MRS. MR-estimated FVF and histological results correlated strongly and FVF allowed the diagnosis of mild (cutoff = 5.5 %) and moderate steatosis (cutoff = 15.2 %) with a sensitivity/specificity of 100 %.Conclusion: FVF calculation worked independently of the field strength. FVF may be a relevant biomarker for the clinical follow-up of patients (1) with or at risk of NAFLD (2) of steatosis in patients with other chronic liver diseases.Key Points: • Non-invasive techniques to diagnose non-alcoholic fatty liver diseases (NAFLD) are important. • Liver fat volume fraction quantified using MRI correlates well with histology. • Fat volume fraction could be a relevant marker for NAFLD clinical follow-up. • Disjointed relaxation time estimation could potentially identify factors contributing to NAFLD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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