Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects.
Purpose: The type 2 cannabinoid receptor (CB2R) is part of the human endocannabinoid system and is involved in central and peripheral inflammatory processes. In vivo imaging of the CB2R would allow study of several (neuro)inflammatory disorders. In this study we have investigated the safety and tole...
| Publicado en: | Molecular Imaging & Biology Vol. 15; no. 4; pp. 384 - 391 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104081247&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104081247 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Aug2013 vid: 15 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104081247 104081247 NLM23508466 2012187826 10.1007/s11307-013-0626-y NLM23508466 104081247 ppf: 384 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects. aug: au: Ahmad, Rawaha Koole, Michel Evens, Nele Serdons, Kim Verbruggen, Alfons Bormans, Guy Van Laere, Koen affil: Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium, rawaha.ahmad@uzleuven.be. sug: subj: Health Quinolines Pharmacokinetics Receptors, Cell Surface Metabolism Adult Aged Diagnostic Imaging Dose-Response Relationship, Radiation Human Immunity Laboratory Chemicals Male Middle Age Radiometry Research Subjects Time Factors Young Adult Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male ab: Purpose: The type 2 cannabinoid receptor (CB2R) is part of the human endocannabinoid system and is involved in central and peripheral inflammatory processes. In vivo imaging of the CB2R would allow study of several (neuro)inflammatory disorders. In this study we have investigated the safety and tolerability of [11C]-NE40, a CB2R positron emission tomography (PET) ligand, in healthy human male subjects and determined its biodistribution and radiation dosimetry.Procedure: Six healthy male subjects (age 20-65 years) underwent a dynamic series of nine whole-body PET/CT scans for up to 140 min, after injection of an average bolus of 286 MBq of [11C]-NE40. Organ absorbed and total effective doses were calculated through OLINDA.Results: [11C]-NE40 showed high initial uptake in the spleen and a predominant hepatobiliary excretion. In the brain, rapid uptake and swift washout were seen. Organ absorbed doses were largest for the small intestine and liver, with 15.6 and 11.5 μGy/MBq, respectively. The mean effective dose was 3.64±0.81 μSv/MBq. There were no changes with aging observed. No adverse events were encountered.Conclusions: This first-in-man study of [11C]-NE40 showed an expected biodistribution compatible with lymphoid tissue uptake and appropriate fast brain kinetics in the healthy human brain, underscoring the potential of this tracer for further application in central and peripheral inflammation imaging. The effective dose is within the typical expected range for 11C ligands. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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