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Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics.

A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BA...

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Published in:Medical & Biological Engineering & Computing Vol. 51; no. 8; pp. 839 - 849
Main Authors: Marom, Gil, Kim, Hee-Sun, Rosenfeld, Moshe, Raanani, Ehud, Haj-Ali, Rami
Format: research Journal Article
Published: Springer Nature Aug2013
Online Access:View this record in EBSCOhost
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      dt: Aug2013
      vid: 51
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      pub: Springer Nature
      place: New York, New York
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        2012188592
        10.1007/s11517-013-1055-4
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        atl: Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics.
      aug:
        au:
          Marom, Gil
          Kim, Hee-Sun
          Rosenfeld, Moshe
          Raanani, Ehud
          Haj-Ali, Rami
        affil: School of Mechanical Engineering, The Fleischman Faculty of Engineering, Tel Aviv University, 6997801, Tel Aviv, Israel, maromgil@eng.tau.ac.il.
      sug:
        subj:
          Aortic Valve Abnormalities
          Heart Valve Diseases Pathology
          Models, Biological
          Aortic Valve Anatomy and Histology
          Aortic Valve Pathology
          Aortic Valve Physiopathology
          Kinematics
          Computer Simulation
          Finite Element Analysis
          Heart Valve Diseases Physiopathology
          Hemodynamics
          Human
          Systole
      ab: A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim of the present study was to characterize the effect of asymmetric BAV on the blood flow using fully coupled fluid-structure interaction (FSI) models with improved boundary conditions and tissue properties. This study presents four FSI models, including a native TAV, asymmetric BAVs with or without a raphe, and an almost symmetric BAV. Cusp tissue is composed of hyperelastic finite elements with collagen fibres embedded in the elastin matrix. A full cardiac cycle is simulated by imposing the same physiological blood pressures for all the TAV and BAV models. The latter have significantly smaller opening areas compared with the TAV. Larger stress values were found in the cusps of BAVs with fused cusps, at both the systolic and diastolic phases. The asymmetric geometry caused asymmetric vortices and much larger flow shear stress on the cusps which could be a potential initiator for early valvular calcification of BAVs.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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