Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.
Although syndecan-4 is implicated in cancer progression, there is no information for its role in testicular germ cell tumours (TGCTs). Thus, we examined the expression of syndecan-4 in patients with TGCTs and its correlation with the clinicopathological findings. Immunohistochemical staining in 71 t...
| Publicado en: | BioMed Research International Vol. 2013; pp. 214864 - 214865 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104081837&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104081837 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104081837 2012189500 NLM23844358 PMC3697279 104081837 ppf: 214864 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours. aug: au: Labropoulou, Vassiliki T Skandalis, Spyros S Ravazoula, Panagiota Perimenis, Petros Karamanos, Nikos K Kalofonos, Haralabos P Theocharis, Achilleas D affil: Hematology Division, Department of Internal Medicine, University Hospital of Patras, 26500 Patras, Greece ; Clinical Oncology Laboratory, Division of Oncology, Department of Medicine, University Hospital of Patras, 26500 Patras, Greece. sug: subj: Neoplasms, Germ Cell and Embryonal Metabolism Glycoproteins Metabolism Testicular Neoplasms Metabolism Adolescence Adult Aged Cell Line, Tumor Immunohistochemistry Male Blood Vessels Pathology Middle Age Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Blood Supply Neoplasms, Germ Cell and Embryonal Pathology Reverse Transcriptase Polymerase Chain Reaction Staining and Labeling Connective Tissue Cells Pathology Testicular Neoplasms Blood Supply Testicular Neoplasms Pathology Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male ab: Although syndecan-4 is implicated in cancer progression, there is no information for its role in testicular germ cell tumours (TGCTs). Thus, we examined the expression of syndecan-4 in patients with TGCTs and its correlation with the clinicopathological findings. Immunohistochemical staining in 71 tissue specimens and mRNA analysis revealed significant overexpression of syndecan-4 in TGCTs. In seminomas, high percentage of tumour cells exhibited membranous and/or cytoplasmic staining for syndecan-4 in all cases. Stromal staining for syndecan-4 was found in seminomas and it was associated with nodal metastasis (P = 0.04), vascular/lymphatic invasion (P = 0.01), and disease stage (P = 0.04). Reduced tumour cell associated staining for syndecan-4 was observed in nonseminomatous germ cell tumours (NSGCTs) compared to seminomas. This loss of syndecan-4 was associated with nodal metastasis (P = 0.01), vascular/lymphatic invasion (P = 0.01), and disease stage (P = 0.01). Stromal staining for syndecan-4 in NSGCTs did not correlate with any of the clinicopathological variables. The stromal expression of syndecan-4 in TGCTs was correlated with microvessel density (P = 0.03). Our results indicate that syndecan-4 is differentially expressed in seminomas and NSGCTs and might be a useful marker. Stromal staining in seminomas and reduced levels of syndecan-4 in tumour cells in NSGCTs are related to metastatic potential, whereas stromal staining in TGCTs is associated with neovascularization. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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