Characterization of antibiotic-loaded alginate-osa starch microbeads produced by ionotropic pregelation.
The aim of this study was to characterize the penicillin-loaded microbeads composed of alginate and octenyl succinic anhydride (OSA) starch prepared by ionotropic pregelation with calcium chloride and to evaluate their in vitro drug delivery profile. The beads were characterized by size, scanning el...
| Publicado en: | BioMed Research International Vol. 2013; pp. 472626 - 472627 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104082049&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104082049 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104082049 104082049 2012190183 NLM23862146 PMC3686067 104082049 ppf: 472626 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Characterization of antibiotic-loaded alginate-osa starch microbeads produced by ionotropic pregelation. aug: au: Fontes, Gizele Cardoso Calado, Verônica Maria Araújo Rossi, Alexandre Malta da Rocha-Leao, Maria Helena Miguez affil: Escola de Química, Universidade Federal do Rio de Janeiro, 21949-900 Rio de Janeiro, RJ, Brazil. sug: subj: Alginates Antibiotics Pharmacodynamics Gels Latex Glucans Calorimetry Acids, Acyclic Hydrogen-Ion Concentration Kinetics Microscopy, Electron, Scanning Particle Size Penicillin G Pharmacodynamics Powders Spectrophotometry, Infrared Static Electricity Surface Properties Chemistry, Analytical X-Rays ab: The aim of this study was to characterize the penicillin-loaded microbeads composed of alginate and octenyl succinic anhydride (OSA) starch prepared by ionotropic pregelation with calcium chloride and to evaluate their in vitro drug delivery profile. The beads were characterized by size, scanning electron microscopy (SEM), zeta potential, swelling behavior, and degree of erosion. Also, the possible interaction between penicillin and biopolymers was investigated by differential scanning calorimetry (DSC), powder Xray diffraction (XRD), and Fourier transform infrared (FTIR) analysis. The SEM micrograph results indicated a homogeneous drug distribution in the matrix. Also, based on thermal analyses (TGA/DSC), interactions were detected between microbead components. Although FTIR spectra of penicillin-loaded microbeads did not reveal the formation of new chemical entities, they confirmed the chemical drug stability. XRD patterns showed that the incorporated crystalline structure of penicillin did not significantly alter the primarily amorphous polymeric network. In addition, the results confirmed a prolonged penicillin delivery system profile. These results imply that alginate and OSA starch beads can be used as a suitable controlled-release carrier for penicillin. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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