Working memory training in survivors of pediatric cancer: a randomized pilot study.
Objectives: Survivors of pediatric brain tumors and acute lymphoblastic leukemia (ALL) are at increased risk for neurocognitive deficits, but few empirically supported treatment options exist. We examined the feasibility and preliminary efficacy of a home-based, computerized working memory training...
| Publicado en: | Psycho-Oncology Vol. 22; no. 8; pp. 1856 - 1866 |
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| Autores principales: | , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104083050&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104083050 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10579249 O9K jtl: Psycho-Oncology issn: 10579249 maglogo: Y pubinfo: dt: Aug2013 vid: 22 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104083050 NLM23203754 2012194362 10.1002/pon.3222 NLM23203754 PMC4131851 104083050 ppf: 1856 ppct: 10 formats: tig: atl: Working memory training in survivors of pediatric cancer: a randomized pilot study. aug: au: Hardy, Kristina K Willard, Victoria W Allen, Taryn M Bonner, Melanie J affil: Center for Neuroscience and Behavioral Medicine, Neuropsychology Division, Children's National Medical Center, Washington, DC, USA; Department of Psychiatry and Behavioral Science, George Washington University School of Medicine, Washington, DC, USA. sug: subj: Brain Neoplasms Psychosocial Factors Memory, Short Term Leukemia, Lymphocytic, Acute Psychosocial Factors Survivors Psychosocial Factors Adolescence Attention Child Cognitive Therapy Therapeutic Exercise Female Human Male Neuropsychological Tests Parents Patient Compliance Pilot Studies Treatment Outcomes Adolescent: 13-18 years Child: 6-12 years Female Male ab: Objectives: Survivors of pediatric brain tumors and acute lymphoblastic leukemia (ALL) are at increased risk for neurocognitive deficits, but few empirically supported treatment options exist. We examined the feasibility and preliminary efficacy of a home-based, computerized working memory training program, CogmedRM, with survivors of childhood cancer.Methods: Survivors of brain tumors or ALL (n = 20) with identified deficits in attention and/or working memory were randomized to either the success-adapted computer intervention or a non-adaptive, active control condition. Specifically, children in the adaptive condition completed exercises that became more challenging with each correct trial, whereas those in the non-adaptive version trained with exercises that never increased in difficulty. All participants were asked to complete 25 training sessions at home, with weekly, phone-based coaching support. Brief assessments were completed pre-intervention and post-intervention; outcome measures included both performance-based and parent-report measures of working memory and attention.Results: Eighty-five percent of survivors were compliant with the intervention, with no adverse events reported. After controlling for baseline intellectual functioning, survivors who completed the intervention program evidenced significant post-training improvements in their visual working memory and in parent-rated learning problems compared with those in the active control group. No differences in verbal working memory functioning were evident between groups, however.Conclusions: Home-based, computerized cognitive training demonstrates good feasibility and acceptability in our sample. Children with higher intellectual functioning at baseline appeared to benefit more from the training, although further study is needed to clarify the strength, scope, and particularly the generalizability of potential treatment effects. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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