Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa.
Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori...
| Publicado en: | BioMed Research International Vol. 2013; pp. 845032 - 845033 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104086575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104086575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104086575 2012221677 NLM23936850 PMC3722974 104086575 ppf: 845032 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa. aug: au: Chojnacki, Cezary Poplawski, Tomasz Blasiak, Janusz Chojnacki, Jan Reiter, Russel J Klupinska, Grazyna affil: Department of Gastroenterology, Medical University of Lodz, 1 Haller's Square, 90-647 Lodz, Poland. sug: subj: Transferases Helicobacter Infections Diagnosis Helicobacter Pylori Melatonin Adult Breath Tests Female Gastric Mucosa Metabolism Gastric Mucosa Microbiology Gastric Mucosa Pathology Genes Helicobacter Infections Microbiology Helicobacter Infections Pathology Male Middle Age RNA Urea Metabolism Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. To diagnose H. pylori infection, histological analysis and the urea breath test (UBT C13) were performed. The levels of mRNA expression of arylalkylamine-N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT) were estimated in gastric mucosa with RT-PCR. The level of AA-NAT expression and AMST was decreased in H. pylori infected patients and was increased after H. pylori eradication. We conclude that decreased expression of melatonin synthesizing enzymes, AA-NAT and ASMT, in patients with symptomatic H. pylori infection returns to normal level after H. pylori eradication. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|