Protein Kinase M-Dependent Maintenance of GluA2 at the Synapse: A Possible Target for Preventing or Treating Age-Related Memory Decline?
Abstract Age-related functional alterations in the perforant path projection from the entorhinal cortex to the dentate gyrus (DG) of the hippocampus play a major role in age-related memory impairments, but little is known about the molecular mechanisms responsible for these changes. In a recent inte...
| Publicado en: | Rejuvenation Research Vol. 16; no. 4; pp. 327 - 330 |
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| Autor principal: | |
| Formato: | research Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104088293&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104088293 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15491684 1E3T jtl: Rejuvenation Research issn: 15491684 maglogo: N pubinfo: dt: Aug2013 vid: 16 iid: 4 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 104088293 104088293 2012226903 10.1089/rej.2013.1448 NLM23679685 104088293 ppf: 327 ppct: 3 formats: tig: atl: Protein Kinase M-Dependent Maintenance of GluA2 at the Synapse: A Possible Target for Preventing or Treating Age-Related Memory Decline? aug: au: Aicardi, Giorgio affil: Department for Life Quality Studies, and Interdepartmental Centre ''Luigi Galvani'' for the Study of Biophysics, Bioinformatics and Biocomplexity, University of Bologna , Bologna, Italy . sug: subj: Aging Memory Disorders Prevention and Control Memory Disorders Therapy Nervous System Metabolism Receptors, Cell Surface Metabolism Transferases Metabolism Animal Studies Hippocampus Physiopathology Memory Disorders Physiopathology Primates ab: Abstract Age-related functional alterations in the perforant path projection from the entorhinal cortex to the dentate gyrus (DG) of the hippocampus play a major role in age-related memory impairments, but little is known about the molecular mechanisms responsible for these changes. In a recent interesting study, Hara and colleagues (J Neurosci 2012;32:7336-7344) tested young and aged monkeys on the visual recognition memory test 'delayed nonmatching-to-sample' (DNMS). Then they performed electron microscopy immunocytochemistry in the hippocampal DG to determine the subcellular localization of the GluA2 subunit of the glutamate [alpha]-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) and protein kinase M (PKM), which promotes memory storage by regulating GluA2-containing AMPAR trafficking. The results obtained suggest that age-related deficits in visual recognition memory are coupled with impairment in PKM-dependent maintenance of GluA2 at the synapse. Together with previous evidence of the critical role of PKM in memory consolidation, these data render this enzyme an attractive potential therapeutic target for preventing or treating age-related memory decline, and support the view that the pharmacological manipulation of AMPAR trafficking in the synapses may provide new insights in the search of memory enhancers for aged individuals, including those affected by Alzheimer disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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