In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Alt...
| Published in: | Medical & Biological Engineering & Computing Vol. 51; no. 10; pp. 1105 - 1120 |
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| Main Authors: | , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104090311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104090311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Oct2013 vid: 51 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104090311 NLM23864549 2012237758 10.1007/s11517-013-1090-1 NLM23864549 104090311 ppf: 1105 ppct: 15 formats: fmt: @attributes: type: P tig: atl: In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. aug: au: Krueger, Martin W Dorn, Andreas Keller, David U J Holmqvist, Fredrik Carlson, Jonas Platonov, Pyotr G Rhode, Kawal S Razavi, Reza Seemann, Gunnar Dössel, Olaf affil: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131, Karlsruhe, Germany, publications@ibt.kit.edu. sug: subj: Atrial Fibrillation Physiopathology Cardiovascular System Physiology Heart Physiopathology Models, Biological Action Potentials Physiology Adult Body Surface Potential Mapping Computer Simulation Electrocardiography Female Heart Atrium Physiopathology Human Male Middle Age Reproducibility of Results Thorax Anatomy and Histology Thorax Physiology Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not been thoroughly investigated. In this study, the original electrophysiological (EP) models of Courtemanche et al., Nygren et al. and Maleckar et al. were adjusted to reproduce action potentials in 13 atrial regions. The parameter sets were validated against experimental action potential duration data and ECG data from patients with AV block. The use of the heterogeneous EP model led to a more synchronized repolarization sequence in a variety of 3D atrial anatomical models. Combination of the heterogeneous EP model with a model of persistent AF-remodeled electrophysiology led to a drastic change in cell electrophysiology. Simulated Ta-waves were significantly shorter under the remodeling. The heterogeneities in cell electrophysiology explain the previously observed Ta-wave effects. The results mark an important step toward the reliable simulation of the atrial repolarization sequence, give a deeper understanding of the mechanism of atrial repolarization and enable further clinical investigations. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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