A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee.
Human and other primate genomes consist of many segmental duplications (SDs) due to fixation of copy number variations (CNVs). Structure of these duplications within the human genome has been shown to be a complex mosaic composed of juxtaposed subunits (called duplicons). These duplicons are difficu...
| Publicado en: | BioMed Research International Vol. 2013; pp. 264532 - 264533 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104090736&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104090736 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104090736 104090736 2012240510 NLM23984331 PMC3747353 104090736 ppf: 264532 ppct: 1 formats: fmt: @attributes: type: P tig: atl: A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee. aug: au: Chuang, Trees-Juen Wu, Shian-Zu Huang, Yao-Ting affil: Genomics Research Center, Academia Sinica, Taipei, Taiwan. sug: subj: DNA Primates Animal Studies Chromosome Disorders Chromosomes Cluster Analysis Evolution Genetics Immunity Probability Sequence Analysis ab: Human and other primate genomes consist of many segmental duplications (SDs) due to fixation of copy number variations (CNVs). Structure of these duplications within the human genome has been shown to be a complex mosaic composed of juxtaposed subunits (called duplicons). These duplicons are difficult to be uncovered from the mosaic repeat structure. In addition, the distribution and evolution of duplicons among primates are still poorly investigated. In this paper, we develop a statistical framework for discovering duplicons via integration of a Hidden Markov Model (HMM) and a permutation test. Our comparative analysis indicates that the mosaic structure of duplicons is common in CNV/SD regions of both human and chimpanzee genomes, and a subset of core dupliconsis shared by the majority of CNVs/SDs. Phylogenetic analyses using duplicons suggested that most CNVs/SDs share common duplication ancestry. Many human/chimpanzee duplicons flank both ends of CNVs, which may be hotspots of nonallelic homologous recombination. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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