Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment.
The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10-35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for perform...
| Publicado en: | Lasers in Medical Science Vol. 28; no. 5; pp. 1323 - 1330 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104091914&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104091914 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02688921 O4P jtl: Lasers in Medical Science issn: 02688921 maglogo: N pubinfo: dt: Sep2013 vid: 28 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104091914 NLM23247663 2012245202 10.1007/s10103-012-1245-6 NLM23247663 104091914 ppf: 1323 ppct: 7 formats: tig: atl: Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment. aug: au: A'amar, O M Liou, L Rodriguez-Diaz, E De Las Morenas, A Bigio, I J affil: Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA, oaamar@bu.edu. sug: subj: Biopsy Methods Prostate Pathology Biopsy Equipment and Supplies Male Equipment and Supplies Prostate Ultrasonography Prostatic Hypertrophy Diagnosis Prostatic Hypertrophy Pathology Prostatic Neoplasms Diagnosis Prostatic Neoplasms Pathology Scattering, Radiation Spectrum Analysis Algorithms Male ab: The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10-35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for performing optically guided biopsy using elastic scattering spectroscopy (ESS) to reduce sampling errors and improve sensitivity. ESS measurements were performed on 42 prostate glands ex vivo and correlated with standard histopathological assessment. Sliced glands were examined with wavelength ranges of 330-760 nm. The ESS portable system used a new fiber-optic probe with integrated cutting tool, designed specifically for ex vivo pathology applications. ESS spectra were grouped by diagnosis from standard histopathological procedure and then classified using linear support vector machine. Preliminary data are encouraging. ESS data showed strong spectral trends correlating with the histopathological assignments. The classification results showed a sensitivity of 0.83 and specificity of 0.87 for distinguishing dysplastic prostatic tissue from benign prostatic tissue. Similar results were obtained for distinguishing dysplastic prostatic tissue from prostatitis with a sensitivity and specificity of 0.80 and 0.88, respectively. The negative predictive values obtained with ESS are better than those obtained with transrectal ultrasound (TRUS)-guided core-needle biopsy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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