Clinical utility and limitations of tumor-feeder detection software for liver cancer embolization.
Purpose: To evaluate the clinical utility and limitations of a computer software program for detecting tumor feeders of hepatocellular carcinoma (HCC) during transarterial chemoembolization (TACE). Materials and Methods: Forty-six patients with 59 HCC nodules underwent nonselective digital subtracti...
| Publicado en: | European Journal of Radiology Vol. 82; no. 10; pp. 1665 - 1672 |
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| Autores principales: | , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Elsevier B.V.
Oct2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104093982&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104093982 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0720048X 3S7 jtl: European Journal of Radiology issn: 0720048X maglogo: N pubinfo: dt: Oct2013 vid: 82 iid: 10 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104093982 NLM23743053 2012254754 10.1016/j.ejrad.2013.05.006 NLM23743053 104093982 ppf: 1665 ppct: 7 formats: tig: atl: Clinical utility and limitations of tumor-feeder detection software for liver cancer embolization. aug: au: Iwazawa, Jin Ohue, Shoichi Hashimoto, Naoko Muramoto, Osamu Mitani, Takashi affil: Department of Radiology, Nissay Hospital, 6-3-8 Itachibori, Nishiku, Osaka 550-0012, Japan. Electronic address: iwazawa.jin@nissay-hp.or.jp. sug: subj: Antineoplastic Agents Administration and Dosage Carcinoma, Hepatocellular Therapy Chemoembolization, Therapeutic Methods Hemostatics Administration and Dosage Hepatic Artery Radiography Liver Neoplasms Therapy Software Adult Aged Aged, 80 and Over Angiography Methods Drug Therapy, Computer Assisted Methods Female Human Male Middle Age Radiographic Image Interpretation, Computer-Assisted Methods Radiography, Interventional Methods Treatment Outcomes Body Weights and Measures Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: To evaluate the clinical utility and limitations of a computer software program for detecting tumor feeders of hepatocellular carcinoma (HCC) during transarterial chemoembolization (TACE). Materials and Methods: Forty-six patients with 59 HCC nodules underwent nonselective digital subtraction angiography (DSA) and C-arm computed tomography (CT) in the same hepatic artery. C-arm CT data sets were analyzed using the software to identify potential tumor feeders during each TACE session. For DSA analysis, 3 radiologists were independently assigned to identify tumor feeders using the DSA images in a separate session. The sensitivity of the 2 techniques in detecting tumor feeders was compared, with TACE findings as the reference standard. Factors affecting the failure of the software to detect tumor feeders were assessed by univariate and multivariate analyses. Results: We detected 65 tumor feeders supplying 59 HCC nodules during TACE sessions. The sensitivity of the software to detect tumor feeders was significantly higher than that of the manual assessment using DSA (87.7% vs. 71.8%, P<0.001). Multivariate analysis showed that a tumor feeder diameter of <1.0mm (hazard ratio [HR], 56.3; P=0.003) and lipiodol accumulation adjacent to the tumor (HR, 11.4; P=0.044) were the significant predictors for failure to detect tumor feeders. Conclusion: The software analysis was superior to manual assessment with DSA in detecting tumor feeders during TACE for HCC. However, the capability of the software to detect tumor feeders was limited by vessel caliber and by prior lipiodol accumulation to the tumor. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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