Dual-energy CT lung ventilation/perfusion imaging for diagnosing pulmonary embolism.
Objectives: To evaluate the feasibility and findings of combined dual-energy computed tomography (DECT) lung ventilation/perfusion imaging in patients with suspected pulmonary embolism (PE).Methods: This study was institutional review board-approved and written informed consent was obtained from eac...
| Publicado en: | European Radiology Vol. 23; no. 10; pp. 2666 - 2676 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104094591&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104094591 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2013 vid: 23 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104094591 NLM23760304 2012259044 10.1007/s00330-013-2907-x NLM23760304 104094591 ppf: 2666 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Dual-energy CT lung ventilation/perfusion imaging for diagnosing pulmonary embolism. aug: au: Zhang, Long Jiang Zhou, Chang Sheng Schoepf, U Joseph Sheng, Hui Xue Wu, Sheng Yong Krazinski, Aleksander W Silverman, Justin R Meinel, Felix G Zhao, Yan E Zhang, Zong Jun Lu, Guang Ming affil: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China. sug: subj: Algorithms Perfusion Imaging Methods Pulmonary Embolism Radiography Radiographic Image Interpretation, Computer-Assisted Methods Radiographic Image Enhancement Methods Tomography, X-Ray Computed Methods Ventilation-Perfusion Ratio Adolescence Adult Child Pilot Studies Female Human Male Middle Age Reproducibility of Results Sensitivity and Specificity Young Adult Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate the feasibility and findings of combined dual-energy computed tomography (DECT) lung ventilation/perfusion imaging in patients with suspected pulmonary embolism (PE).Methods: This study was institutional review board-approved and written informed consent was obtained from each patient. Thirty-two subjects (aged 11-61 years) underwent combined xenon-enhanced ventilation and iodine-enhanced perfusion DECT. Ventilation, perfusion and morphological information were visually interpreted. Ventilation/perfusion information was classified as mismatch (differing patterns) or match (concordant patterns). Adverse reactions and radiation doses were recorded for each subject.Results: Of 32 patients undergoing xenon-enhanced DECT, six patients reported adverse reactions (shortness of breath, n = 2; mild dizziness, n = 3; limb numbness, n = 1). Twenty-eight of 32 patients could be included into the data analysis. PE was detected in 10/28 patients. PE-related ventilation/perfusion mismatch was found in 17 lung lobes in 8/10 patients and matched ventilation/perfusion was detected in 2 patients. Eighteen patients had no PE. In this group, there was no case of a ventilation/perfusion mismatch. Matched ventilation/perfusion impairment was seen in one patient. The overall radiation dose from two DECT acquisitions was 4.8 ± 1.4 mSv (range 2.7-7.5 mSv).Conclusions: DECT lung ventilation/perfusion imaging is feasible and can visualise ventilation/perfusion match or mismatch in patients with suspected PE.Key Points: • Combined dual-energy CT lung ventilation/perfusion imaging is feasible. • Combined dual-energy CT ventilation/perfusion imaging provides lung morphological and functional information. • Dual-energy CT can demonstrate ventilation/perfusion mismatch in patients with pulmonary embolism. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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