A systematic review of health-related quality of life instruments in patients with cancer cachexia.
Purpose: Assessing the health-related quality of life (HRQOL) of cancer patients with cachexia is particularly important because treatments for cachexia are currently aimed at palliation and treatment efficacy must be measured in ways other than survival. The aim of this systematic review was to eva...
| Publicado en: | Supportive Care in Cancer Vol. 21; no. 9; pp. 2625 - 2637 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review Journal Article |
| Publicado: |
Springer Nature
Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104097740&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104097740 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Sep2013 vid: 21 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104097740 NLM23797577 2012307536 10.1007/s00520-013-1881-9 NLM23797577 104097740 ppf: 2625 ppct: 12 formats: fmt: @attributes: type: P tig: atl: A systematic review of health-related quality of life instruments in patients with cancer cachexia. aug: au: Wheelwright, Sally Darlington, Anne-Sophie Hopkinson, Jane B Fitzsimmons, Deborah White, Alice Johnson, Colin D affil: Cancer Sciences, University of Southampton, Southampton, UK. S.J.Wheelwright@soton.ac.uk sug: subj: Anorexia Etiology Cachexia Etiology Health Status Neoplasms Complications Quality of Life Anorexia Drug Therapy Cachexia Drug Therapy Human Neoplasms Psychosocial Factors Systematic Review Treatment Outcomes ab: Purpose: Assessing the health-related quality of life (HRQOL) of cancer patients with cachexia is particularly important because treatments for cachexia are currently aimed at palliation and treatment efficacy must be measured in ways other than survival. The aim of this systematic review was to evaluate HRQOL assessment in cancer patients with cachexia.Methods: Using guidance from the Centre for Reviews and Dissemination, relevant databases were searched from January 1980 to January 2012 with terms relating to cancer, cachexia and HRQOL for papers including adult cancer patients with cachexia or documented weight loss at baseline.Results: We found one cachexia-specific instrument, the Functional Assessment of Anorexia/Cachexia Therapy, but the tool has not been fully validated, does not cover all the relevant domains and the consensus-based standards for the selection of health status measurement instruments checklist highlighted a number of weaknesses in the methodological quality of the validation study. Sixty-seven studies assessed HRQOL in cachectic or weight-losing cancer patients. Most used generic cancer HRQOL instruments, limiting the amount of useful information they provide. A modified version of the Efficace minimum data checklist demonstrated that the quality of reporting on HRQOL tool use was inadequate in many of the studies. A negative relationship between HRQOL and weight loss was found in 23 of the 27 studies which directly examined this.Conclusion: There is a pressing need for a well-designed HRQOL tool for use with this patient group in both clinical trials and clinical practice. pubtype: Academic Journal doctype: research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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