Development and characterization of novel polyurethane films impregnated with tolfenamic Acid for therapeutic applications.
The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1:5 in Tetrahydrofuran (THF) or...
| Publicado en: | BioMed Research International Vol. 2013; pp. 178973 - 178974 |
|---|---|
| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104098879&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104098879 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104098879 2012313459 NLM24073394 PMC3773997 104098879 ppf: 178973 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Development and characterization of novel polyurethane films impregnated with tolfenamic Acid for therapeutic applications. aug: au: Istanbullu, Hilal Ahmed, Sofia Sheraz, Muhammad Ali Rehman, Ihtesham Ur affil: Department of Materials Science and Engineering, The Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield S3 7HQ, UK. sug: subj: Drug Delivery Systems Polyurethanes Acids, Carbocyclic Pharmacodynamics Calorimetry Microscopy, Electron, Scanning Spectrophotometry, Infrared X-Rays Acids, Carbocyclic ab: The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1:5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1: 2 to 1 : 5 ratios, respectively. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|