Is health-related quality of life associated with upper and lower airway inflammation in asthmatics?
Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-Q...
| Publicado en: | BioMed Research International Vol. 2013; pp. 539290 - 539291 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104098892&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104098892 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104098892 104098892 2012313472 NLM24073408 PMC3773386 104098892 ppf: 539290 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Is health-related quality of life associated with upper and lower airway inflammation in asthmatics? aug: au: Scichilone, Nicola Braido, Fulvio Taormina, Salvatore Pozzecco, Elena Paternò, Alessandra Baiardini, Ilaria Casolaro, Vincenzo Canonica, Giorgio Walter Bellia, Vincenzo affil: Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Sezione di Pneumologia, University of Palermo, 90146 Palermo, Italy. sug: subj: Asthma Complications Asthma Pathology Health Inflammation Complications Inflammation Pathology Lung Pathology Quality of Life Adult Asthma Physiopathology Biological Markers Metabolism Clinical Assessment Tools Female Human Inflammation Physiopathology Lung Physiopathology Male Nitric Oxide Metabolism Pulmonary Alveoli Metabolism Pulmonary Alveoli Pathology Pulmonary Alveoli Physiopathology Questionnaires Respiratory Function Tests Scales Adult: 19-44 years Female Male ab: Background. Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL. Methods. Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash. Results. The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: r = 0.34, P = 0.24; ECP: r = 0.06, P = 0.87) or bronchial inflammation (pH of the EBC: r = 0.12, P = 0.44; bronchial NO: r = 0.27, P = 0.22;alveolarNO: r = 0.38, P = 0.10). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT < 20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (r = 0.60, P = 0.04). Conclusions. Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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