Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification.
Antipsychotic drugs are medications commonly for schizophrenia (SCZ) treatment, which include two groups: typical and atypical. SCZ patients have multiple comorbidities, and the coadministration of drugs is quite common. This may result in adverse drug-drug interactions, which are events that occur...
| Publicado en: | BioMed Research International Vol. 2013; pp. 458989 - 458990 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104101725&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104101725 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104101725 104101725 2012332028 NLM24089679 PMC3782118 104101725 ppf: 458989 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification. aug: au: Sun, Jingchun Zhao, Min Fanous, Ayman H Zhao, Zhongming affil: Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA ; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA. sug: subj: Antipsychotic Agents Adverse Effects Drug Interactions Adverse Drug Event Schizophrenia Drug Therapy Antipsychotic Agents Administration and Dosage Antipsychotic Agents Classification Resource Databases Human ab: Antipsychotic drugs are medications commonly for schizophrenia (SCZ) treatment, which include two groups: typical and atypical. SCZ patients have multiple comorbidities, and the coadministration of drugs is quite common. This may result in adverse drug-drug interactions, which are events that occur when the effect of a drug is altered by the coadministration of another drug. Therefore, it is important to provide a comprehensive view of these interactions for further coadministration improvement. Here, we extracted SCZ drugs and their adverse drug interactions from the DrugBank and compiled a SCZ-specific adverse drug interaction network. This network included 28 SCZ drugs, 241 non-SCZs, and 991 interactions. By integrating the Anatomical Therapeutic Chemical (ATC) classification with the network analysis, we characterized those interactions. Our results indicated that SCZ drugs tended to have more adverse drug interactions than other drugs. Furthermore, SCZ typical drugs had significant interactions with drugs of the "alimentary tract and metabolism" category while SCZ atypical drugs had significant interactions with drugs of the categories "nervous system" and "antiinfectives for systemic uses." This study is the first to characterize the adverse drug interactions in the course of SCZ treatment and might provide useful information for the future SCZ treatment. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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