Allergy or tolerance: reduced inflammatory cytokine response and concomitant IL-10 production of lymphocytes and monocytes in symptom-free titanium dental implant patients.
Hypersensitivity reactions to titanium (Ti) are very rare. Thus, we assessed the proinflammatory response and also potential tolerance favoring in vitro reactivity ofhuman blood lymphocytes and monocytes (PBMC) to Ti in healthy individuals (14 without, 6 with complication-free dental Ti implants). T...
| Publicado en: | BioMed Research International Vol. 2013; pp. 539834 - 539835 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104104967&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104104967 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104104967 2012341089 NLM24106709 PMC3784072 104104967 ppf: 539834 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Allergy or tolerance: reduced inflammatory cytokine response and concomitant IL-10 production of lymphocytes and monocytes in symptom-free titanium dental implant patients. aug: au: Thomas, Peter Iglhaut, Gerhard Wollenberg, Andreas Cadosch, Dieter Summer, Burkhard affil: Department of Dermatology and Allergology, Ludwig-Maximilians-University of Munich, Frauenlobstraße 9-11, 80337 Munich, Germany. sug: subj: Dental Implants Adverse Effects Interleukins Titanium Adverse Effects Adult Cells, Cultured Drug Effects Cells, Cultured Metabolism Cytokines Female Hypersensitivity Metabolism Hypersensitivity Pathology Immunity Interleukins Metabolism Lymphocytes Immunology Lymphocytes Metabolism Lymphocytes Pathology Male Middle Age Monocytes Immunology Monocytes Metabolism Monocytes Pathology Titanium Administration and Dosage Titanium Therapeutic Use Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Hypersensitivity reactions to titanium (Ti) are very rare. Thus, we assessed the proinflammatory response and also potential tolerance favoring in vitro reactivity ofhuman blood lymphocytes and monocytes (PBMC) to Ti in healthy individuals (14 without, 6 with complication-free dental Ti implants). The proliferation index (SI) in lymphocyte transformation test (LTT) and production of cytokines linked to innate immune response (IL-1β, IL-6, and TNFα) or immune regulation (IL-10) were assessed in response to TiO2 particles or Ti discs. In both groups, the Ti-LTT reactivity was not enhanced (e.g., SI < 3). The control antigen tetanus toxoid (TT) gave adequate reactivity (median SI individuals without/with implant: 20.6 ± 5.97/19.58 ± 2.99). Individuals without implant showed higher cytokine response to Ti materials than individuals with symptom-free implants; for example, TiO2 rutile particle induced increase of IL-1β 70.27-fold/8.49-fold versus control medium culture. PBMC of 5 of the 6 individuals with complicationfree Ti implants showed an ex vivo ongoing production of IL-10 (mean 4.18 ± 2.98 pg/mL)-but none of the 14 controls showed such IL-10 production. Thus in vitro IL-1β-, IL-6-, and TNF-α production reflects "normal" unspecific immune response to Ti. This might be reduced by production of tolerogenic IL-10 in individuals with symptom-free Ti dental implants. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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