Combining areal DXA bone mineral density and vertebrae postero-anterior width improves the prediction of vertebral strength.
Objective: Areal bone mineral density (aBMD) measured by dual-energy X-ray absorptiometry (DXA) is an important determinant of bone strength (BS), despite the fact that the correlation between aBMD and BS is relatively weak. Parameters that describe BS more accurately are desired. The aim of this st...
| Publicado en: | Skeletal Radiology Vol. 42; no. 12; pp. 1717 - 1726 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104106424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104106424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Dec2013 vid: 42 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104106424 NLM24081424 2012343305 10.1007/s00256-013-1723-3 NLM24081424 PMC3824230 104106424 ppf: 1717 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Combining areal DXA bone mineral density and vertebrae postero-anterior width improves the prediction of vertebral strength. aug: au: Taton, Grzegorz Rokita, Eugeniusz Wróbel, Andrzej Korkosz, Mariusz Tatoń, Grzegorz affil: Department of Biophysics, Jagiellonian University Medical College, Łazarza 16, 31530, Kraków, Poland sug: subj: Absorptiometry, Photon Methods Bone Density Physiology Imaging, Three-Dimensional Methods Lumbar Vertebrae Physiology Lumbar Vertebrae Radiography Radiographic Image Interpretation, Computer-Assisted Methods Weight-Bearing Physiology Adult Aged Aged, 80 and Over Cadaver Compressive Strength Physiology Human Male Middle Age Body Weights and Measures Reproducibility of Results Sensitivity and Specificity Stress, Mechanical Tensile Strength Physiology Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male ab: Objective: Areal bone mineral density (aBMD) measured by dual-energy X-ray absorptiometry (DXA) is an important determinant of bone strength (BS), despite the fact that the correlation between aBMD and BS is relatively weak. Parameters that describe BS more accurately are desired. The aim of this study was to determine whether the geometrical corrections applied to aBMD would improve its ability for BS prediction. We considered new parameters, estimated from a single DXA measurement, as well as BMAD (bone mineral apparent density) reported in the literature.Materials and Methods: In vitro studies were performed with the L3 vertebrae from 20 cadavers, which were studied with DXA and quantitative computed tomography (QCT). A mechanical strength assessment was carried out. Two new parameters were introduced: vBMD(min) = aBMD/W(PA)(min) and vBMD(av) = aBMD/W(PA)(av) (W PA(min) -minimal vertebral body width in postero-anterior (PA) view, W(PA)(av) - average PA vertebral body width). Volumetric BMD measured by QCT (vBMD), aBMD, BMAD, vBMD(min), and vBMD(av) were correlated to ultimate load and ultimate stress (P(max)) to find the best predictor of vertebrae BS.Results: The coefficients of correlation between P(max) and vBMD(min), vBMD(av), as well as BMAD, were r = 0.626 (p = 0.005), r = 0.610 (p = 0.006) and r = 0.567 (p = 0.012), respectively. Coefficients for vBMD and aBMD are r = 0.648 (p = 0.003) and r = 0.511 (p = 0.03), respectively.Conclusions: Our results showed that aBMD normalized by vertebrae dimensions describes vertebrae BS better than aBMD alone. The considered indices vBMD(av), vBMD(min), and BMAD can be measured in routine PA DXA and considerably improve BS variability prediction. vBMD(min) is superior compared to vBMD(av) and BMAD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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