Biomimetic mineralization on a macroporous cellulose-based matrix for bone regeneration.
The aim of this study is to investigate the biomimetic mineralization on a cellulose-based porous matrix with an improved biological profile. The cellulose matrix was precalcified using three methods: (i) cellulose samples were treated with a solution of calcium chloride and diammonium hydrogen phos...
| Publicado en: | BioMed Research International Vol. 2013; pp. 452750 - 452751 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104107932&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104107932 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104107932 104107932 2012349808 NLM24163816 PMC3791641 104107932 ppf: 452750 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Biomimetic mineralization on a macroporous cellulose-based matrix for bone regeneration. aug: au: Petrauskaite, Odeta Gomes, Pedro de Sousa Fernandes, Maria Helena Juodzbalys, Gintaras Stumbras, Arturas Maminskas, Julius Liesiene, Jolanta Cicciù, Marco affil: Department of Organic Technology, Kaunas University of Technology, Radvilenu pl. 19, 50254 Kaunas, Lithuania. sug: subj: Industry Bone Regeneration Drug Effects Cellulose Connective Tissue Cells Bone Development Drug Effects Calcium Chloride Pharmacodynamics Cell Physiology Drug Effects Cellulose Metabolism Minerals Minerals Therapeutic Use Human Connective Tissue Cells Drug Effects Connective Tissue Cells Metabolism Phosphates Pharmacodynamics Surface Properties ab: The aim of this study is to investigate the biomimetic mineralization on a cellulose-based porous matrix with an improved biological profile. The cellulose matrix was precalcified using three methods: (i) cellulose samples were treated with a solution of calcium chloride and diammonium hydrogen phosphate; (ii) the carboxymethylated cellulose matrix was stored in a saturated calcium hydroxide solution; (iii) the cellulose matrix was mixed with a calcium silicate solution in order to introduce silanol groups and to combine them with calcium ions. All the methods resulted in a mineralization of the cellulose surfaces after immersion in a simulated body fluid solution. Over a period of 14 days, the matrix was completely covered with hydroxyapatite crystals. Hydroxyapatite formation depended on functional groups on the matrix surface as well as on the precalcification method. The largest hydroxyapatite crystals were obtained on the carboxymethylated cellulose matrix treated with calcium hydroxide solution. The porous cellulose matrix was not cytotoxic, allowing the adhesion and proliferation of human osteoblastic cells. Comparatively, improved cell adhesion and growth rate were achieved on the mineralized cellulose matrices. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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