New guar biopolymer silver nanocomposites for wound healing applications.
Wound healing is an innate physiological response that helps restore cellular and anatomic continuity of a tissue. Selective biodegradable and biocompatible polymer materials have provided useful scaffolds for wound healing and assisted cellular messaging. In the present study, guar gum, a polymeric...
| Publicado en: | BioMed Research International Vol. 2013; pp. 912458 - 912459 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104109008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104109008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104109008 104109008 2012354934 NLM24175306 PMC3794655 104109008 ppf: 912458 ppct: 1 formats: fmt: @attributes: type: P tig: atl: New guar biopolymer silver nanocomposites for wound healing applications. aug: au: Ghosh Auddy, Runa Abdullah, Md Farooque Das, Suvadra Roy, Partha Datta, Sriparna Mukherjee, Arup affil: Department of Chemical Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, West Bengal 700009, India. sug: subj: Metals Therapeutic Use Nanotechnology Therapeutic Use Silver Therapeutic Use Wound Healing Drug Effects Animal Studies Antiinfective Agents Antiinfective Agents Administration and Dosage Antiinfective Agents Therapeutic Use Granulation Tissue Drug Effects Granulation Tissue Pathology Male Materials Testing Metals Microscopy, Electron, Scanning Nanotechnology Plant Gums Plant Gums Therapeutic Use Polysaccharides Polysaccharides Therapeutic Use Rabbits Rats Silver Silver Administration and Dosage Spectrophotometry Tensile Strength Wound Healing Physiology X-Rays Male ab: Wound healing is an innate physiological response that helps restore cellular and anatomic continuity of a tissue. Selective biodegradable and biocompatible polymer materials have provided useful scaffolds for wound healing and assisted cellular messaging. In the present study, guar gum, a polymeric galactomannan, was intrinsically modified to a new cationic biopolymer guar gum alkylamine (GGAA) for wound healing applications. Biologically synthesized silver nanoparticles (Agnp) were further impregnated in GGAA for extended evaluations in punch wound models in rodents. SEM studies showed silver nanoparticles well dispersed in the new guar matrix with a particle size of ~18 nm. In wound healing experiments, faster healing and improved cosmetic appearance were observed in the new nanobiomaterial treated group compared to commercially available silver alginate cream. The total protein, DNA, and hydroxyproline contents of the wound tissues were also significantly higher in the treated group as compared with the silver alginate cream (P < 0.05). Silver nanoparticles exerted positive effects because of their antimicrobial properties. The nanobiomaterial was observed to promote wound closure by inducing proliferation and migration of the keratinocytes at the wound site. The derivatized guar gum matrix additionally provided a hydrated surface necessary for cell proliferation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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