Genome-Wide Analysis of Human MicroRNA Stability.
Increasing studies have shown that microRNA (miRNA) stability plays important roles in physiology. However, the global picture of miRNA stability remains largely unknown. Here, we had analyzed genome-wide miRNA stability across 10 diverse cell types using miRNA arrays. We found that miRNA stability...
| Publicado en: | BioMed Research International Vol. 2013; pp. 368975 - 368976 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104110468&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104110468 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104110468 2012357481 NLM24187663 PMC3804285 104110468 ppf: 368975 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Genome-Wide Analysis of Human MicroRNA Stability. aug: au: Li, Yang Li, Zhixin Zhou, Shixin Wen, Jinhua Geng, Bin Yang, Jichun Cui, Qinghua affil: Department of Cell Biology, Stem Cell Research Center, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China. sug: subj: Bioinformatics RNA Biochemical Phenomena Proteins Genes Genome, Human Oligonucleotide Array Sequence Analysis Proteins Metabolism ab: Increasing studies have shown that microRNA (miRNA) stability plays important roles in physiology. However, the global picture of miRNA stability remains largely unknown. Here, we had analyzed genome-wide miRNA stability across 10 diverse cell types using miRNA arrays. We found that miRNA stability shows high dynamics and diversity both within individual cells and across cell types. Strikingly, we observed a negative correlation between miRNA stability and miRNA expression level, which is different from current findings on other biological molecules such as proteins and mRNAs that show positive and not negative correlations between stability and expression level. This finding indicates that miRNA has a distinct action mode, which we called "rapid production, rapid turnover; slow production, slow turnover." This mode further suggests that high expression miRNAs normally degrade fast and may endow the cell with special properties that facilitate cellular status-transition. Moreover, we revealed that the stability of miRNAs is affected by cohorts of factors that include miRNA targets, transcription factors, nucleotide content, evolution, associated disease, and environmental factors. Together, our results provided an extensive description of the global landscape, dynamics, and distinct mode of human miRNA stability, which provide help in investigating their functions in physiology and pathophysiology. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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