Increasing Affinity of Interferon-[gamma] Receptor 1 to Interferon-[gamma] by Computer-Aided Design.
We describe a computer-based protocol to design protein mutations increasing binding affinity between ligand and its receptor. The method was applied to mutate interferon-¿ receptor 1 (IFN-¿-Rx) to increase its affinity to natural ligand IFN-¿, protein important for innate immunity. We analyzed all...
| Published in: | BioMed Research International Vol. 2013; pp. 752514 - 752515 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Published: |
Wiley-Blackwell
2013
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| Online Access: | View this record in EBSCOhost |