Possible mechanisms of fullerene C 60 antioxidant action.
Novel mechanism of antioxidant activity of buckminsterfullerene C¿¿ based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene's...
| Publicado en: | BioMed Research International Vol. 2013; pp. 821498 - 821499 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104113708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104113708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104113708 104113708 2012371317 NLM24222918 PMC3816026 104113708 ppf: 821498 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Possible mechanisms of fullerene C 60 antioxidant action. aug: au: Chistyakov, V A Smirnova, Yu O Prazdnova, E V Soldatov, A V affil: Research Institute of Biology, Southern Federal University, Rostov-on-Don 344090, Russia. sug: subj: Antioxidants Therapeutic Use Carbon Therapeutic Use Mitochondria Metabolism Antioxidants Metabolism Carbon Metabolism Human Mitochondria Drug Effects Mitochondria Physiology Oxidation-Reduction Metabolism Drug Effects Protons Reactive Oxygen Species Metabolism Respiration Drug Effects ab: Novel mechanism of antioxidant activity of buckminsterfullerene C¿¿ based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene's geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen species scavengers. We propose here that C¿¿ has an ability to acquire positive charge by absorbing inside several protons and this complex could penetrate into mitochondria. Such a process allows for mild uncoupling of respiration and phosphorylation. This, in turn, leads to the decrease in ROS production. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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