Quantification of cerebellar hemispheric purkinje cell linear density: 32 ET cases versus 16 controls.
Although essential tremor (ET) is among the most prevalent neurological diseases, its precise pathogenesis is not understood. Purkinje cell loss has been observed in some studies and is the focus of interest and debate. Expressing these data as Purkinje cells/layer length allows one to adjust for th...
| Publicado en: | Movement Disorders Vol. 28; no. 13; pp. 1854 - 1860 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104114513&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104114513 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08853185 O71 jtl: Movement Disorders issn: 08853185 maglogo: Y pubinfo: dt: Nov2013 vid: 28 iid: 13 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104114513 NLM23925732 2012372472 10.1002/mds.25629 NLM23925732 PMC3830681 104114513 ppf: 1854 ppct: 6 formats: tig: atl: Quantification of cerebellar hemispheric purkinje cell linear density: 32 ET cases versus 16 controls. aug: au: Louis, Elan D Babij, Rachel Lee, Michelle Cortés, Etty Vonsattel, Jean-Paul G affil: GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA. sug: subj: Cerebellum Pathology Essential Tremor Pathology Dominance, Cerebral Neurons Pathology Aged Aged, 80 and Over Calcium Binding Proteins Metabolism Cell Count Female Human Male Neurons Metabolism Nonparametric Statistics Aged: 65+ years Aged, 80 & over Female Male ab: Although essential tremor (ET) is among the most prevalent neurological diseases, its precise pathogenesis is not understood. Purkinje cell loss has been observed in some studies and is the focus of interest and debate. Expressing these data as Purkinje cells/layer length allows one to adjust for the inherent curved nature of the cerebellar folia. Capitalizing on the Essential Tremor Centralized Brain Repository, we quantified Purkinje cell linear density in cases versus controls. Free-floating 100-μm parasagittal cerebellar hemispheric sections were subjected to rabbit polyclonal anti-Calbindin D28k antibody, and 10 random fields/brain were selected for quantification of Purkinje cells/mm(-1) Purkinje cell layer. Purkinje cell linear density was lower in 32 ET cases than in16 controls (1.14 ± 0.32 vs. 1.35 ± 0.31/mm(-1) , P = 0.03). Purkinje cell linear density was inversely associated with torpedo count (r = -0.38, P = 0.028). The current sample of ET cases demonstrates a reduction in Purkinje cell number relative to that of controls. Greater Purkinje cell axonal remodeling (torpedoes) was found in individuals who had the most Purkinje cell drop out. The role of Purkinje cell loss in the pathogenesis of this disorder merits additional study. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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