Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome.
Patients with 22q11.2 deletion syndrome (22q11.2DS) represent a population at high risk for developing schizophrenia, as well as learning disabilities. Deficits in visuo-spatial memory are thought to underlie some of the cognitive disabilities. Neuronal substrates of visuo-spatial memory include the...
| Publicado en: | Brain Imaging & Behavior Vol. 7; no. 3; pp. 316 - 326 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104115367&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104115367 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2013 vid: 7 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104115367 NLM23612843 2012373778 10.1007/s11682-013-9232-5 NLM23612843 PMC3796180 104115367 ppf: 316 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome. aug: au: Kikinis, Zora Makris, Nikos Finn, Christine T Bouix, Sylvain Lucia, Diandra Coleman, Michael J Tworog-Dube, Erica Kikinis, Ron Kucherlapati, Raju Shenton, Martha E Kubicki, Marek affil: Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA, 02115, USA, zora@bwh.harvard.edu. sug: subj: Demyelinating Diseases Demyelinating Diseases Pathology DiGeorge Syndrome DiGeorge Syndrome Pathology Nerve Fibers Pathology Neural Pathways Pathology Neural Pathways Physiopathology Adult Magnetic Resonance Imaging Female Disease Susceptibility Male Adult: 19-44 years Female Male ab: Patients with 22q11.2 deletion syndrome (22q11.2DS) represent a population at high risk for developing schizophrenia, as well as learning disabilities. Deficits in visuo-spatial memory are thought to underlie some of the cognitive disabilities. Neuronal substrates of visuo-spatial memory include the inferior fronto-occipital fasciculus (IFOF) and the inferior longitudinal fasciculus (ILF), two tracts that comprise the ventral visual stream. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) is an established method to evaluate white matter (WM) connections in vivo. DT-MRI scans of nine 22q11.2DS young adults and nine matched healthy subjects were acquired. Tractography of the IFOF and the ILF was performed. DT-MRI indices, including Fractional anisotropy (FA, measure of WM changes), axial diffusivity (AD, measure of axonal changes) and radial diffusivity (RD, measure of myelin changes) of each of the tracts and each group were measured and compared. The 22q11.2DS group showed statistically significant reductions of FA in IFOF in the left hemisphere. Additionally, reductions of AD were found in the IFOF and the ILF in both hemispheres. These findings might be the consequence of axonal changes, which is possibly due to fewer, thinner, or less organized fibers. No changes in RD were detected in any of the tracts delineated, which is in contrast to findings in schizophrenia patients where increases in RD are believed to be indicative of demyelination. We conclude that reduced axonal changes may be key to understanding the underlying pathology of WM leading to the visuo-spatial phenotype in 22q11.2DS. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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