Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients.
Background: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multic...
| Publicado en: | Orphanet Journal of Rare Diseases Vol. 8; no. 1; pp. 136 - 137 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104115820&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104115820 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17501172 38NP jtl: Orphanet Journal of Rare Diseases issn: 17501172 maglogo: N pubinfo: dt: 2013 vid: 8 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104115820 104115820 NLM24010984 2012374420 10.1186/1750-1172-8-136 NLM24010984 PMC3844435 104115820 ppf: 136 ppct: 1 formats: tig: atl: Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. aug: au: Al Ghazal, Philipp Herberger, Katharina Schaller, Jörg Strölin, Anke Hoff, Norman-Philipp Goerge, Tobias Roth, Hannelore Rabe, Eberhard Karrer, Sigrid Renner, Regina Maschke, Jan Horn, Thomas Hepp, Julia Eming, Sabine Wollina, Uwe Zutt, Markus Sick, Isabell Splieth, Benno Dill, Dorothea Klode, Joachim sug: subj: Pyoderma Gangrenosum Diagnosis Pyoderma Gangrenosum Epidemiology Adult Aged Aged, 80 and Over Endocrine Diseases Complications Female Germany Human Inflammatory Bowel Diseases Complications Male Middle Age Neoplasms Complications Pyoderma Gangrenosum Etiology Retrospective Design Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Background: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.Methods: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.Results: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.Conclusions: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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