Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.
Objective: The purpose of this study was to investigate clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.Method: Thirty-six medication-naïve children ages 9-14 years diagnosed with attention-deficit/hyperactivity disorder (ADHD) were enrolled for 6 weeks i...
| Publicado en: | Journal of Child & Adolescent Psychopharmacology Vol. 23; no. 9; pp. 597 - 605 |
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| Autores principales: | , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Nov2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104117658&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104117658 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10445463 C1K jtl: Journal of Child & Adolescent Psychopharmacology issn: 10445463 maglogo: N pubinfo: dt: Nov2013 vid: 23 iid: 9 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 104117658 92037762 NLM23659360 2012382319 10.1089/cap.2012.0085 NLM23659360 PMC3842881 104117658 ppf: 597 ppct: 8 formats: tig: atl: Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials. aug: au: Ramtvedt, Bjørn E Røinås, Elisabeth Aabech, Henning S Sundet, Kjetil S affil: 1 østfold Hospital Trust , Neuropsychiatric Unit, Fredrikstad, Norway . sug: subj: Attention Deficit Hyperactivity Disorder Drug Therapy Central Nervous System Stimulants Therapeutic Use Dextroamphetamine Therapeutic Use Methylphenidate Therapeutic Use Adolescence Attention Deficit Hyperactivity Disorder Physiopathology Central Nervous System Stimulants Administration and Dosage Child Clinical Assessment Tools Crossover Design Dextroamphetamine Administration and Dosage Diagnosis, Computer Assisted Double-Blind Studies Female Human Male Methylphenidate Administration and Dosage Parents Questionnaires Time Factors Treatment Outcomes Adolescent: 13-18 years Child: 6-12 years Female Male ab: Objective: The purpose of this study was to investigate clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.Method: Thirty-six medication-naïve children ages 9-14 years diagnosed with attention-deficit/hyperactivity disorder (ADHD) were enrolled for 6 weeks in a crossover trial, with 2 weeks of methylphenidate, dextroamphetamine, and placebo, in a randomly assigned, counterbalanced sequence. Outcome measures constituted a computer-based continuous performance test combined with a motion tracking system (Qb Test) and an ADHD questionnaire rated by parents and teachers.Results: Group analyses found significant treatment effects of similar size for the two stimulants on both outcome measures. Single-subject analyses revealed that each stimulant produced a favourable response in 26 children; however, an individual child frequently responded qualitatively or quantitatively differently to the two stimulants. By including both stimulants in the trial, the number of favorable responders increased from 26 (72%) to 33 (92%). In children with favorable responses of unequal strength to the two stimulants, a shift from inferior drug to best drug was associated with a 64% mean increase in the overall response strength score, as measured by the ADHD questionnaire.Conclusions: The likelihood of a favorable response and optimal response strength is increased by including both stimulants in the stimulant trial. The study was first registered in clinical trials 28 September 2010. Clinical Trials.gov Identifier: NCT01220440. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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