Pulmonary inflammatory myofibroblastic tumor and IgG4-related inflammatory pseudotumor: a diagnostic dilemma.
IgG4-related inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) share morphological features like a prominent fibroblastic/myofibroblastic proliferation and the presence of inflammatory cells. Since IPT is managed conservatively and IMT is treated by surgical excision, it is...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 463; no. 6; pp. 743 - 748 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104119826&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104119826 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Dec2013 vid: 463 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104119826 NLM24100523 2012399819 10.1007/s00428-013-1493-2 NLM24100523 104119826 ppf: 743 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pulmonary inflammatory myofibroblastic tumor and IgG4-related inflammatory pseudotumor: a diagnostic dilemma. aug: au: Bhagat, Priyanka Bal, Amanjit Das, Ashim Singh, Navneet Singh, Harkant affil: Department of Histopathology, Post Graduate Institute of Medical Sciences & Research (PGIMER), Sector - 12, Chandigarh, 160012, India. sug: subj: Diagnosis, Differential Lung Neoplasms Diagnosis Neoplasms, Muscle Tissue Diagnosis Lung Diseases Diagnosis Adolescence Adult Child Female Human Immunoglobulins Immunohistochemistry Inflammation Diagnosis Inflammation Metabolism Lung Neoplasms Metabolism Male Middle Age Neoplasms, Muscle Tissue Metabolism Lung Diseases Metabolism Retrospective Design Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Middle Aged: 45-64 years Female Male ab: IgG4-related inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) share morphological features like a prominent fibroblastic/myofibroblastic proliferation and the presence of inflammatory cells. Since IPT is managed conservatively and IMT is treated by surgical excision, it is important to differentiate these two lesions. The aim of this study is to highlight morphological and immunohistochemical features that distinguish IPT and IMT. Clinicopathological characteristics of cases diagnosed as pulmonary IPT or IMT from 1997 to 2013 were reviewed. The histological features were studied on hematoxylin and eosin-stained sections. Immunohistochemistry was done for IgG, IgG4, ALK-1, SMA, desmin, and CD34 for classification into IPT and IMT. Of the ten patients, seven were male and the age ranged from 4 to 58 years. The tumor size ranged from 1.5 to 4.0 cm in diameter. Histologically, proliferation of bland-looking spindle cells along with fibrosis and an inflammatory infiltrate comprising of lymphocytes and plasma cells were the common morphological features of both lesions. The spindle cell proliferation was more marked in IMT whereas lymphoplasmacytic infiltrate was more prominent in IPT. Obstructive phlebitis was observed only in cases of IPT. IgG4 expression was noted in IPT, and the number of IgG4-positive plasma cells and the ratio of IgG4+/IgG+ plasma cells were significantly lower in IMT than in IgG4-related IPT. Expression of anaplastic lymphoma kinase (ALK) was observed only in IMT, but not in IgG4-related IPT. The proportion of proliferating spindle cells, lymphoplasmacytic infiltrate, obstructive phlebitis, IgG4+ plasma cells and the ratio of IgG4+/IgG+ plasma cells, and ALK expression are helpful in differentiating these morphologically similar but biologically different lesions, which require different treatment modalities. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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