A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis...
| Publicado en: | BioMed Research International Vol. 2013; pp. 180453 - 180454 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104120687&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104120687 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104120687 104120687 2012401184 NLM24288664 PMC3833019 104120687 ppf: 180453 ppct: 1 formats: fmt: @attributes: type: P tig: atl: A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis. aug: au: Moreau, Maxim Pelletier, Jean-Pierre Lussier, Bertrand d'Anjou, Marc-André Blond, Laurent Pelletier, Johanne-Martel Del Castillo, Jérôme R E Troncy, Eric affil: Osteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, Canada H2L 4M1 ; GREPAQ, Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine (FVM), Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, QC, Canada J2S 7C6. sug: subj: Models, Biological Osteoarthritis Surgery Animal Studies Anterior Cruciate Ligament Pathology Anterior Cruciate Ligament Physiopathology Anterior Cruciate Ligament Surgery Cartilage Pathology Dogs Kinematics Magnetic Resonance Imaging Motor Activity Osteoarthritis Pathology Osteoarthritis Physiopathology Regression ab: For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent testretest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreementwith the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|