Microfluidics for Synthesis of Peptide-Based PET Tracers.
Positron emission tomography (PET) is a powerful noninvasive tool for acquisition of the physiological parameters in human and animals with the help of PET tracers. Among all the PET tracers, radiolabeled peptides have been widely explored for cancer-related receptor imaging due to their high affini...
| Publicado en: | BioMed Research International Vol. 2013; pp. 839683 - 839684 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104120712&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104120712 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104120712 2012401208 NLM24288688 PMC3833028 104120712 ppf: 839683 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Microfluidics for Synthesis of Peptide-Based PET Tracers. aug: au: Liu, Yang Tian, Mei Zhang, Hong affil: Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China. sug: subj: Contrast Media Microfluidic Analytical Techniques Methods Tomography, Emission-Computed Radiopharmaceuticals Microfluidic Analytical Techniques Equipment and Supplies ab: Positron emission tomography (PET) is a powerful noninvasive tool for acquisition of the physiological parameters in human and animals with the help of PET tracers. Among all the PET tracers, radiolabeled peptides have been widely explored for cancer-related receptor imaging due to their high affinity and specificity to receptors. But radiochemistry procedures for production of peptide-based PET tracers are usually complex, which makes large-scale clinical studies relatively challenging. New radiolabeling technologies which could simplify synthesis and purification procedures, are extremely needed. Over the last decade, microfluidics and lab-on-a-chip (LOC) technology have boomed as powerful tools in the field of organic chemistry, which potentially provide significant help to the PET chemistry. In this minireview, microfluidic radiolabeling technology is described and its application for synthesis of peptide-based PET tracers is summarized and discussed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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