Pyoderma gangrenosum in refractory celiac disease: a case report.
Background: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammatory and neoplastic diseases. Here we report the first case of pyoderma gangrenosum in a patient with refractory celiac disease.Case P...
| Published in: | BMC Gastroenterology Vol. 13; no. 1; pp. 162 - 163 |
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| Main Authors: | , , , , , , |
| Format: | case study Journal Article |
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BioMed Central
2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104120810&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104120810 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2013 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104120810 104120810 NLM24279608 2012401362 10.1186/1471-230X-13-162 NLM24279608 104120810 ppf: 162 ppct: 1 formats: tig: atl: Pyoderma gangrenosum in refractory celiac disease: a case report. aug: au: Sedda, Silvia Caruso, Roberta Marafini, Irene Campione, Elena Orlandi, Augusto Pallone, Francesco Monteleone, Giovanni affil: Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133 Rome, Italy. Gi.Monteleone@Med.uniroma2.it. sug: subj: Celiac Disease Complications Pyoderma Gangrenosum Complications Female Middle Age Middle Aged: 45-64 years Female ab: Background: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammatory and neoplastic diseases. Here we report the first case of pyoderma gangrenosum in a patient with refractory celiac disease.Case Presentation: A 52-year-old woman with a previously diagnosed refractory celiac disease resistant to steroids and immunosuppressive drugs presented to our hospital for a rapidly growing, painful inflammatory skin lesion of the left leg. Physical examination revealed a painful lesion with focal ulceration, necrosis and pus discharge with active inflammatory borders at the external part of the left leg. Histological evaluation of a skin biopsy and analysis of inflammatory cytokines and matrix-degrading proteases in lesional skin samples confirmed the clinical suspicion of pyoderma gangrenosum. Treatment with oral prednisone was rapidly followed by a complete healing of the skin lesion but no improvement of symptoms/signs of malabsorption.Conclusion: Treatment of the patient with systemic steroids healed the skin lesion without improving the underlying refractory celiac disease. This observation raises the possibility that refractory celiac disease and pyoderma gangrenosum may be immunologically different. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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