Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor- [beta] Knockout Mice.
The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and ß subunit of receptors of platelet-derived growth factor (PDGFR- ß ) have been suggested to play an important role in development of the visual system an...
| Publicado en: | BioMed Research International Vol. 2013; pp. 848265 - 848266 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104122848&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104122848 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104122848 104122848 2012404884 NLM24319691 PMC3844215 104122848 ppf: 848265 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor- [beta] Knockout Mice. aug: au: Zhao, Juanjuan Urakawa, Susumu Matsumoto, Jumpei Li, Ruixi Ishii, Yoko Sasahara, Masakiyo Peng, Yuwen Ono, Taketoshi Nishijo, Hisao affil: System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan ; Department of Anatomy, Histology and Embryology, Shanghai Medical School, Fudan University, Shanghai 200032, China. sug: subj: Albumins Metabolism Brain Stem Metabolism Proteins Metabolism Receptors, Cell Surface Deficiency Animal Studies Behavior, Animal Brain Stem Pathology Brain Stem Physiopathology Immunohistochemistry Male Mice Neurons Metabolism Neurons Pathology Receptors, Cell Surface Social Behavior Male ab: The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and ß subunit of receptors of platelet-derived growth factor (PDGFR- ß ) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR- ß -knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR- ß KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR- ß KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR- ß KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR- ß KO mice. These findings suggest that PDGFR- ß plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|