Prolonged delivery of ciprofloxacin and diclofenac sodium from a polymeric fibre device for the treatment of peridontal disease.
In vitro analysis of drug release and antimicrobial activity of the coblended crosslinked polymeric fibre device (PFD) were investigated. The fibre loaded with ciprofloxacin and diclofenac sodium was comprised of alginate and glycerol crosslinked with barium cations. The pH dependent drug release wa...
| Publicado en: | BioMed Research International Vol. 2013; pp. 460936 - 460937 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104123344&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104123344 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104123344 104123344 2012405693 NLM24324962 PMC3845435 104123344 ppf: 460936 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Prolonged delivery of ciprofloxacin and diclofenac sodium from a polymeric fibre device for the treatment of peridontal disease. aug: au: Johnston, Deanne Choonara, Yahya E Kumar, Pradeep du Toit, Lisa C van Vuuren, Sandy Pillay, Viness affil: Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. sug: subj: Antibiotics Administration and Dosage Ciprofloxacin Administration and Dosage Diclofenac Administration and Dosage Periodontal Diseases Drug Therapy Antibiotics Ciprofloxacin Diclofenac Drug Delivery Systems Enterococcus Drug Effects Escherichia Coli Drug Effects Human Hydrogen-Ion Concentration Microbial Culture and Sensitivity Tests Periodontal Diseases Microbiology Periodontal Diseases Pathology Polymers Streptococcus Mutans Drug Effects ab: In vitro analysis of drug release and antimicrobial activity of the coblended crosslinked polymeric fibre device (PFD) were investigated. The fibre loaded with ciprofloxacin and diclofenac sodium was comprised of alginate and glycerol crosslinked with barium cations. The pH dependent drug release was evident with ciprofloxacin and diclofenac sodium diffusing from the fibre at pH 4.0 compared to pH 6.8, where the fibre swelled and eroded resulting in zero-order drug release. Agar diffusion studies followed by minimum inhibitory assays were conducted to determine the antimicrobial activity of the device against Escherichia coli, Enterococcus faecalis, and Streptococcus mutans. The antimicrobial activity of the PFD was confirmed in both test assays against all test pathogens. The MIC ranges at pH 4.0 for E. coli, E. faecalis, and S. mutans were 0.5-0.8, 0.4-1.1, and 0.7-2.1 μg/mL, respectively. At pH 6.8, similar efficacies (0.3-0.5 μg/mL for E. coli and E. faecalis and 0.6-1.0 μg/mL for S. mutans) were observed. The effect of varying the plasticizer and crosslinking ion concentration on drug release profile of the fibers was further elucidated and conceptualized using molecular mechanics energy relationships (MMER) and by exploring the spatial disposition of geometrically minimized molecular conformations. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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