Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy.
Context: Cisplatin, a coordination platinum complex, is used as a potential anti-neoplastic agent, having well recognized DNA-damaging property that triggers cell-cycle arrest and cell death in cancer therapy. Beneficial chemotherapeutic actions of cisplatin can be detrimental for kidneys. Backgroun...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 69; no. 11; pp. 1863 - 1875 |
|---|---|
| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104143312&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104143312 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Nov2013 vid: 69 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104143312 90672873 10.1007/s00228-013-1568-7 NLM23929259 104143312 ppf: 1863 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy. aug: au: Jaiman, Siddesh Sharma, Arun Singh, Kulwant Khanna, Deepa affil: Cardiovascular Pharmacology Division, Department of Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa 125 055 India sug: subj: Cisplatin Administration and Dosage Signal Transduction Cisplatin Adverse Effects Kidney Pathology Nephrons Pathology Neoplasms Drug Therapy Protein Kinases Reactive Oxygen Species Tumor Necrosis Factor Inflammation Glutathione Apoptosis ab: Context: Cisplatin, a coordination platinum complex, is used as a potential anti-neoplastic agent, having well recognized DNA-damaging property that triggers cell-cycle arrest and cell death in cancer therapy. Beneficial chemotherapeutic actions of cisplatin can be detrimental for kidneys. Background: Unbound cisplatin gets accumulated in renal tubular cells, leading to cell injury and death. This liable action of cisplatin on kidneys is mediated by altered intracellular signalling pathways such as mitogen-activated protein kinase (MAPK), extracellular regulated kinase (ERK), or C- Jun N terminal kinase/stress-activated protein kinase (JNK/SAPK). Further, these signalling alterations are responsible for release and activation of tumour necrosis factor (TNF-α), mitochondrial dysfunction, and apoptosis, which ultimately cause the renal pathogenic process. Cisplatin itself enhances the generation of reactive oxygen species (ROS) and activation of nuclear factor-κB (NF-κB), inflammation, and mitochondrial dysfunction, which further leads to renal apoptosis. Cisplatin-induced nephropathy is also mediated through the p53 and protein kinase-Cδ (PKCδ) signalling pathways. Objective: This review explores these signalling alterations and their possible role in the pathogenesis of cisplatin-induced renal injury. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|