Cryptococcal meningoencephalitis: a case report and literature review.
Objective To study the clinical and pathological features of central nervous system (CNS) cryptococcosis. Methods and Results A 26-year-old male patient presented with headache and fever. Glucose, chloride and protein level was abnormal in cerebrospinal fluid (CSF) examination, but the pathogen was...
| Publicado en: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 13; no. 10; pp. 876 - 882 |
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| Autores principales: | , , |
| Formato: | case study research Journal Article |
| Publicado: |
Chinese Journal of Contemporary Neurology & Neurosurgery
Oct2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104149200&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104149200 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: Oct2013 vid: 13 iid: 10 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 104149200 91544692 10.3969/j.issn.1672-6731.2013.10.013 104149200 ppf: 876 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Cryptococcal meningoencephalitis: a case report and literature review. aug: au: ZHANG Xue-bin YAN Xiao-ling TANG Fan affil: Department of Pathology, Tianjin Huanhu Hospital, Tianjin 300060, China sug: subj: Cryptococcosis Diagnosis Meningoencephalitis Diagnosis Neurology Neurosurgery Human Brain Diseases Diagnosis Male Adult Magnetic Resonance Imaging Cysts Periodic Acid-Schiff Reaction Cerebrospinal Fluid Analysis Cerebellar Diseases Diagnosis Temporal Lobe Brain Surgery Methods Surgery, Operative Central Nervous System Fungal Infections Diagnosis Immunohistochemistry Cryptococcosis Physiopathology Adult: 19-44 years Male ab: Objective To study the clinical and pathological features of central nervous system (CNS) cryptococcosis. Methods and Results A 26-year-old male patient presented with headache and fever. Glucose, chloride and protein level was abnormal in cerebrospinal fluid (CSF) examination, but the pathogen was not found. MRI showed patchy abnormal signal at right cerebellum, the fourth ventricle and posterior horn of lateral ventricle. During the operation, cystic lesions located in right temporal lobe and grayish black choroid plexus were found, and temporal lobe lesions and degeneration of choroid plexus were partially resected. After operation, 3 pieces of greyish green tissues were resected, measuring 1.50 cm × 0.60 cm × 0.50 cm. Optical microscopic examination found a large number of birefractive oval and (or) circular cryptococcus in the brain tissue and choroid plexus, with foreign body giant cell reaction and lymphocytic infiltration. Cryptococcus could also be seen in giant cells, and spore formation was found in part of them. Periodic acid - Schiff (PAS) and periodic acid silver methenamine (PASM) staining showed positive expression of cryptococcus. Conclusion Cryptococcosis is a common CNS fungal infection caused by cryptococcus neoformans. A large number of cryptococcus neoformans in brain tissue or lacuna is the characteristic pathological manifestation, and positive expression in PAS and PASM staining can be shown in CSF. pubtype: Academic Journal doctype: case study research Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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