Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells.
Ellagic acid is a polyphenolic phytochemical present in many fruits and nuts with anticancer properties demonstrated in experimental tumor studies. Embelin is a benzoquinone phytochemical isolated from the Japanese herbArdisiae Japonicaeand has been shown to induce apoptosis in cancer cells. We foun...
| Publicado en: | Nutrition & Cancer Vol. 65; no. 8; pp. 1232 - 1245 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104157717&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104157717 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Nov2013 vid: 65 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104157717 91967771 10.1080/01635581.2013.832779 NLM24127740 104157717 ppf: 1232 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells. aug: au: Edderkaoui, Mouad Lugea, Aurelia Hui, Hongxiang Eibl, Guido Lu, Qing-Yi Moro, Aune Lu, Xuyang Li, Gang Go, Vay-Liang Pandol, Stephen J. affil: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA; UCLA Center for Excellence in Pancreatic Diseases, University of California Los Angeles, Los Angeles, California, USA; Cedars-Sinai Medical Center, Los Angeles, California, USA sug: subj: Acids Phenols Therapeutic Use Phytochemicals Plants, Medicinal Therapeutic Use Pancreatic Neoplasms Physiopathology Nutrition Fruit Therapeutic Use Human Cell Physiology Cell Culture Techniques In Vitro Studies DNA Physiology Enzyme-Linked Immunosorbent Assay Intercellular Signaling Peptides and Proteins Pancreatic Neoplasms Mortality ab: Ellagic acid is a polyphenolic phytochemical present in many fruits and nuts with anticancer properties demonstrated in experimental tumor studies. Embelin is a benzoquinone phytochemical isolated from the Japanese herbArdisiae Japonicaeand has been shown to induce apoptosis in cancer cells. We found that ellagic acid and embelin each dose-dependently increased apoptosis and inhibited proliferation in human pancreatic cancer cells, MIA PaCa-2 and HPAF-II cells, and in pancreatic stellate cells, which are progenitors of pancreatic cancer desmoplasia. In each of these cell types, combinations of ellagic acid and embelin at low micromolar concentrations (0.5–3 μM) induced synergistic increases in apoptosis and decreases in proliferation. Ellagic acid decreased NF-κB transcriptional activity, whereas embelin decreased STAT-3 phosphorylation and protein expression of its downstream target survivin in cancer cells. In vivo dietary ellagic acid alone or in combination with embelin decreased tumor size and tumor cellularity in a subcutaneous xenograft mouse model of pancreatic cancer. These results show that ellagic acid and embelin interact with divergent intracellular signaling pathways resulting in augmentation of apoptosis and inhibition of proliferation at low micromolar concentrations for the key cellular components of pancreatic adenocarcinoma. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|