Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study.
Purpose: To determine the effect of 4 weeks of supplementation, then, withdrawal of a dietary supplement (DS) containing red yeast rice extract, policosanol and artichoke leaf extract at twice the recommended daily dose (6 tablets, 6-TAB) compared to the usual dose (3-TAB) or to a placebo (PLA), on...
| Publicado en: | European Journal of Nutrition Vol. 52; no. 8; pp. 1843 - 1853 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Dec2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104160714&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104160714 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2013 vid: 52 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104160714 92013192 10.1007/s00394-012-0486-2 NLM23266743 104160714 ppf: 1843 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study. aug: au: Barrat, Emmanuel Zaïr, Yassine Sirvent, Pascal Chauveau, Patrice Maudet, Corinne Housez, Béatrice Derbord, Elodie Lescuyer, Jean-François Bard, Jean-Marie Cazaubiel, Murielle Peltier, Sébastien L. affil: Department of Research, Laboratoire Lescuyer, BP 33, 17442, Aytré Cedex, France sug: subj: Lipoproteins, LDL Cholesterol Dietary Supplementation Plant Extracts Therapeutic Use Hypercholesterolemia Drug Therapy Human France Randomized Controlled Trials Double-Blind Studies Placebos Confidence Intervals Odds Ratio Young Adult Adult Middle Age Male Female Data Analysis Software Questionnaires Severity of Illness In Vivo Studies Rats Lipoproteins, LDL Cholesterol Blood Descriptive Statistics Analysis of Covariance Analysis of Variance Paired T-Tests Physical Activity Energy Intake Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: To determine the effect of 4 weeks of supplementation, then, withdrawal of a dietary supplement (DS) containing red yeast rice extract, policosanol and artichoke leaf extract at twice the recommended daily dose (6 tablets, 6-TAB) compared to the usual dose (3-TAB) or to a placebo (PLA), on blood lipid profiles and safety biomarkers. Methods: Forty-five healthy subjects (15 per group), with untreated hypercholesterolaemia, were included in this randomised, double-blind, placebo-controlled clinical trial. Results: After 4 weeks of supplementation, LDL-C was significantly lower in 6-TAB (−0.21 g/l; 95 % CI −0.38 to −0.03 g/l; p = 0.0217) and 3-TAB (−0.25 g/l; 95 % CI −0.42 to −0.07 g/l; p = 0.0071) compared to PLA, although no difference in LDL-cholesterol was observed between the two groups, while no effect was seen on triacylglycerol and HDL-cholesterol. Four weeks after the end of supplementation, no difference in LDL-C was seen between the PLA group and the DS-treated groups. The muscle breakdown biomarkers, as well as biomarkers of liver and renal function, were altered by neither dose of the DS. Acute application of the DS on permeabilised skeletal muscle fibres of rats did not induce deleterious effects on mitochondrial function. Conclusions: Supplementation with twice the recommended dose of the DS was effective in reducing LDL-cholesterol and appeared safe, but according to the present results, no additional benefit could be achieved compared to the recommended dose. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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