Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects.
Purpose: The effect of brewers’ yeast (1,3)-(1,6)-beta- d-glucan consumption on the number of common cold episodes in healthy subject was investigated. Methods: In a placebo-controlled, double-blind, randomized, multicentric clinical trial, 162 healthy participants with recurring infections received...
| Publicado en: | European Journal of Nutrition Vol. 52; no. 8; pp. 1913 - 1919 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Dec2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104160723&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104160723 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2013 vid: 52 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104160723 92013599 10.1007/s00394-013-0492-z 104160723 ppf: 1913 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects. aug: au: Auinger, Annegret Riede, Linda Bothe, Gordana Busch, Regina Gruenwald, Joerg affil: analyze & realize ag, Waldseeweg 6, 13467, Berlin, Germany sug: subj: Yeasts Glucans Common Cold Immunology Common Cold Drug Therapy Treatment Outcomes Human Germany Randomized Controlled Trials Double-Blind Studies Placebos Multicenter Studies Diaries Young Adult Adult Middle Age Aged Data Analysis Software Mann-Whitney U Test Descriptive Statistics Severity of Illness Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Purpose: The effect of brewers’ yeast (1,3)-(1,6)-beta- d-glucan consumption on the number of common cold episodes in healthy subject was investigated. Methods: In a placebo-controlled, double-blind, randomized, multicentric clinical trial, 162 healthy participants with recurring infections received 900 mg of either placebo ( n = 81) or an insoluble yeast (1,3)-(1,6)-beta- d-glucan preparation ( n = 81) per day over a course of 16 weeks. Subjects were instructed to document each occurring common cold episode in a diary and to rate ten predefined infection symptoms during an infections period, resulting in a symptom score. The subjects were examined by the investigator during the episode visit on the 5th day of each cold episode. Results: In the per protocol population, supplementation with insoluble yeast (1,3)-(1,6)-beta-glucan reduced the number of symptomatic common cold infections by 25 % as compared to placebo ( p = 0.041). The mean symptom score was 15 % lower in the beta-glucan as opposed to the placebo group ( p = 0.125). Beta-glucan significantly reduced sleep difficulties caused by cold episode as compared to placebo ( p = 0.028). Efficacy of yeast beta-glucan was rated better than the placebo both by physicians ( p = 0.004) participants ( p = 0.012). Conclusion: The present study demonstrated that yeast beta-glucan preparation increased the body’s potential to defend against invading pathogens. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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