Dermal Absorption of Chemicals: Estimation by IH SkinPerm.
This article describes the IH SkinPerm mathematical tool for estimating dermal absorption. The first part provides the scientific background of the IH SkinPerm model, including the QSARs and the developed differential equations. Then the practical value of the tool is demonstrated through example de...
| Publicado en: | Journal of Occupational & Environmental Hygiene Vol. 11; no. 1; pp. 19 - 32 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jan2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104168352&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104168352 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Jan2014 vid: 11 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104168352 92664724 10.1080/15459624.2013.831983 NLM24283333 104168352 ppf: 19 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Dermal Absorption of Chemicals: Estimation by IH SkinPerm. aug: au: Tibaldi, Rosalie ten Berge, Wil Drolet, Daniel affil: ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey sug: subj: Occupational Exposure Volatilization Absorption Human New Jersey Models, Statistical Skin Physiology ab: This article describes the IH SkinPerm mathematical tool for estimating dermal absorption. The first part provides the scientific background of the IH SkinPerm model, including the QSARs and the developed differential equations. Then the practical value of the tool is demonstrated through example dermal absorption assessments for substances with skin notations. IH SkinPerm simulates three types of dermal absorption scenarios relevant to occupational environments. The first is dermal absorption from instantaneous splash type exposures onto bare skin for pure liquids. The second estimates dermal absorption from the deposition of pure liquids over time. The third enables estimation of dermal uptake from an airborne vapor concentration. A simulation with IH SkinPerm was made using vapor absorption data published from volunteer exposure studies. Comparison of measured and estimated dermal absorbed dose showed IH SkinPerm estimated dermal absorbed dose was within a factor of 3 compared to the reported study values. IH SkinPerm accounts for substance volatility and evaporated mass and provides real-time description of dermal absorption with graphical displays and numerical outputs. To assess absorption resulting from dermal exposure scenarios, the mass of the substance loaded onto the skin, substance physical chemical properties, exposure duration, and the skin surface area affected are the only required input parameters. pubtype: Academic Journal doctype: equations & formulas pictorial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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