Methodological Issues in Studying Rates and Predictors of Migraine Progression and Remission.
Background.- The progression and remission of migraine and the risk factors that determine the course of illness have been intensively studied for the past decade. Methods.- In this fourth paper in a series of methodological articles, we summarize crucial issues that influence studies of migraine cl...
| Publicado en: | Headache: The Journal of Head & Face Pain Vol. 53; no. 6; pp. 930 - 935 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104172630&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104172630 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00178748 4AP jtl: Headache: The Journal of Head & Face Pain issn: 00178748 maglogo: Y pubinfo: dt: Jun2013 vid: 53 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104172630 2012132836 10.1111/head.12128 NLM23721240 104172630 ppf: 930 ppct: 5 formats: tig: atl: Methodological Issues in Studying Rates and Predictors of Migraine Progression and Remission. aug: au: Lipton, Richard B. Penzien, Donald B. Turner, Dana P. Smitherman, Todd A Houle, Timothy T. affil: Departments of Neurology, Epidemiology and Population Health and the Montefiore Headache Center, Albert Einstein College of Medicine sug: subj: Research Methodology Migraine Classification Disease Progression Disease Remission Chronic Disease Classification Headache Symptoms ab: Background.- The progression and remission of migraine and the risk factors that determine the course of illness have been intensively studied for the past decade. Methods.- In this fourth paper in a series of methodological articles, we summarize crucial issues that influence studies of migraine clinical course, and suggest directions and opportunities for future research. Results.- Defining chronic migraine (CM) based on 15 or more headache days per month is problematic because headache frequency varies from month to month. We propose methods of defining CM as a trait and not as a state of headache frequency. Our notions of progression and remission, defined by the crossing of an arbitrary frequency boundary, are also problematic; we propose alternative approaches. Measuring headache frequency is challenging because of measurement error, temporal sampling error, and real change over time. Conclusions.- We suggest alternative approaches for defining migraine subtypes, measuring change in frequency, defining progression and remission, and modeling change over time. Our suggestions are intended to encourage dialogue and need refinement and evaluation. Our long-term goal is to improve classification and measurement to facilitate the discovery of risk factors, genes, and other biological processes that determine the onset and course of migraine. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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